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Submissions from 2017

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A Dilute-and-Shoot Flow-Injection Tandem Mass Spectrometry Method for Quantification of Phenobarbital in Urine, Ravali Alagandula, Xiang Zhou, and Baochuan Guo

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Straightforward Synthesis of N-Glycan Polymers from Free Glycans via Cyanoxyl Free Radical-Mediated Polymerization, Jinshan Tang, Evgeny Ozhegov, Yang Liu, Dan Wang, Xinsheng Yao, and Xue-Long Sun

Submissions from 2016

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Chapter 7 – Chemotherapeutic Intervention by Inhibiting DNA Polymerases, A. Dasari, Jung-Suk Choi, and Anthony J. Berdis

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Synthesis, Electrochemical Characterization, and Linear Free Energy Relationship of 1,3-Diphenyl-6-alkyl/arylfulvenes, Nicholas P. Godman, Sonya K. Adas, Karl M. Hellwig, David W. Ball, Gary J. Balaich, and Scott T. Iacono

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Oncogenic PIK3CA Mutations Reprogram Glutamine Metabolism in Colorectal Cancer, Yujun Hao, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, Bohan Dong, Bo Cao, Xiujing Feng, Min Xiang, Claire Xu, Stephen Fink, Neal J. Meropol, and Yan Xu

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Determination of MLN0128, An Investigational Antineoplastic Agent, in Human Plasma by LC–MS/MS, Sandeep R. Kunati and Yan Xu

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Measurement of Ring Strain Using Butanols: A Physical Chemistry Lab Experiment, William R. Martin, Ada S. Davidson, and David W. Ball

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Preparation and Structures of Two Mixed-Ligand 4-methylpyridine Indium Bromide Complexes, John Masnovi, Eric B. Clark, Aloysius F. Hepp, John D. Schupp, and Philip E. Fanwick

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Inhibition of Yeast Ribonucleotide Reductase by Sml1 Depends on the Allosteric State of the Enzyme, Tessianna A. Misko, Sanath R. Wijerathna, Tomas Radivoyevitch, Anthony J. Berdis, Md. Faiz Ahmad, Michael E. Harris, and Chris G. Dealwis

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Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function, Yana Sandlers, Kelly Mercier, Wimal Pathmasiri, Jim Carlson, Susan McRitchie, Susan Sumner, and Hilary J. Vernon

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Preparation of Chain-End Clickable Recombinant Protein and its Bio-Orthogonal Modification, Lin Wang, Rui Jiang, Lin Wang, Yang Liu, and Xue-Long Sun

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The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin, Joesph R. Wiencek, Jamila Hirbawi, Vivien C. Yee, and Michael Kalafatis

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Synthesis of an End-to-End Protein–Glycopolymer Conjugate via Bio-Orthogonal Chemistry, Hailong Zhang, Jacob Weingart, Valentinas Gruzdys, and Xue-Long Sun

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Targeting Radioresistant Breast Cancer Cells by Single Agent CHK1 Inhibitor via Enhancing Replication Stress, Yao Zhang, Jinzhi Lai, Zhanwen Du, Jinnan Gao, Shuming Yang, Shashank Gorityala, Xiahui Xiong, Ou Deng, Zhefu Ma, Chunhong Yan, Gonzalo Susana, Yan Xu, and Junran Zhang

Submissions from 2014

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Development of A Liquid Chromatographic Method for Quantitative Determination of Triapine, A Ribonucleotide Reductase Inhibitor, by Spectrophotometric Study of Triapine Complexation Reaction, Ye Feng, Melissa McCulloch, and Yang Xu

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Bioassay Guided Identification of Small Chaperone Proteins α-crystallin and Hsp27 Inhibitors from Copaiba Oil, Rati Lama, Bo Zhong, Daniel G. Kulman, and Bin Su Ph.D.

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A Kinetic Analysis of The Inhibition of FOX-4 β-Lactamase, A Plasmid-Mediated AmpC Cephalosporinase, By Monocyclic β-lactams and Carbapenems, Krisztina M. Papp-Wallace, Susana Mallo, Christopher R. Bethel, Magdalena A. Taracila, Andrea M. Hujer, Ana Fernandez, Julian A. Gatta, Kerri M. Smith, Yan Xu, Malcolm G.P. Page, Eric Desarbre, German Bou, and Robert A. Bonomo

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Reclaiming The Efficacy of β-Lactam–β-Lactamase Inhibitor Combinations: Avibactam Restores The Susceptibility of CMY-2-Producing Escherichia Coli to Ceftazidime, Krisztina M. Papp-Wallace, Marisa L. Winkler, Julian A. Gatta, Magdalena A. Taracila, Sujatha Chilakala, Yan Xu, J. Kristie Johnson, and Robert A. Bonomo

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Liposome Surface Functionalization Based on Different Anchoring Lipids via Staudinger Ligation, Pratima Vabbilisetty and Xue-Long Sun

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Development and Validation of LC–MS/MS Method for Quantitative Determination of (−)-Securinine in Mouse Plasma, Simuli L. Wabuyele, David Wald, and Yang Xu

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Mediatorless Immunoassay with Voltage-Controlled Intrinsic Amplification for Ultrasensitive and Rapid Detection of Microorganism Pathogens, Jiapeng Wang, Yan Xu, and Siu Tang Yau

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Lead Optimization of Dual Tubulin and Hsp27 Inhibitors, Bo Zhong, Rati Lama, Daniel G. Kulman, Bibo Li Ph.D., and Bin Su Ph.D.

Submissions from 2013

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Can Inhibitor-Resistant Substitutions in The Mycobacterium Tuberculosis β-Lactamase BlaC Lead to Clavulanate Resistance?: A Biochemical Rationale for The Use of β-Lactam–β-Lactamase Inhibitor Combinations

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Development and Characterization of A Non-natural Nucleoside That Displays Anticancer Activity Against Solid Tumors

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Synthesis and Anticancer Mechanism Investigation of Dual Hsp27 and Tubulin Inhibitors

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Logger Rhythm, David W. Ball

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Wien’s Displacement Law as a Function of Frequency, David W. Ball

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Spectroscopic Analysis of Polymerization and Exonuclease Proofreading By A High-Fidelity DNA Polymerase During Translesion DNA Synthesis, Babho Devadoss, Irene Lee, and Anthony J. Berdis

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Development and Characterization of A Non-natural Nucleoside that Displays Anticancer Activity Against Solid Tumors, Jackelyn Golden, Edward A. Motea, Xuemei Zhang, Jung-Suk Choi, Ye Feng, Yan Xu, Irene Lee, and Anthony J. Berdis

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A Phase 1 Study of TRC102, An Inhibitor of Base Excision Repair, and Pemetrexed in Patients with Advanced Solid Tumors, Michael S. Gordon, Lee S. Rosen, David Mendelson, Ramesh K. Ramanathan, Jonathan Goldman, Lili Liu, Yan Xu, Stanton L. Gerson, Stephen P. Anthony, William D. Figg, Shawn Spencer, Bonne J. Adams, Charles P. Theuer, Bryan R. Leigh, and Glen J. Weiss

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Inhibition of Metastasis by HEXIM1 Through Effects on Cell Invasion and Angiogenesis, W. Ketchart, Kerri M. Smith, T. Krupka, B. M. Wittmann, Y. Hu, P. A. Rayman, Y. Q. Doughman, J. M. Albert, X. Bai, J. H. Finke, Yan Xu, A. A. Exner, and M. M. Montano

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Why is the Sky Blue?, James A. Locke and David W. Ball

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Cyclometalated Iridium(III) Complexes with Deoxyribose Substituents, Ayan Maity, Jung-Suk Choi, Thomas S. Teets, Nihal Deligonul, Anthony J. Berdis, and Thomas G. Gray

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Metastable Nanostructured Metallized Fluoropolymer Composites for Energetics, Hannah A. Miller, Bradley S. Kusel, Seth T. Danielson, James W. Neat, Eryn K. Avjian, Scott N. Pierson, Stephen M. Budy, David W. Ball, Scott T. Iacono, and Sharon C. Kettwich

Insights Into The Roles of Desolvation and π-Electron Interactions During DNA Polymerization, Edward A. Motea, Irene Lee, and Anthony J. Berdis

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β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of An Unprecedented Stabilized Acyl-Enzyme, Elizabeth A. Rodkey, David C. Mcleod, Christopher R. Bethel, Kerri M. Smith, Yan Xu, Weirui Chai, Tao Che, Paul R. Carey, Robert A. Bonomo, Focco van den Akker, and John D. Buynak

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Membrane Mimetic Surface Functionalization of Nanoparticles: Methods and Applications, Jacob Weingart, Pratima Vabbilisetty, and Xue-Long Sun

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Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with A Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase, Marisa L. Winkler, Elizabeth A. Rodkey, Magdalena A. Taracila, Sarah M. Drawz, Christopher R. Bethel, Krisztina M. Papp-Wallace, Kerri M. Smith, Yan Xu, Jeffrey R. Dwulit-Smith, Chiara Romagnoli, Emilia Caselli, Fabio Prati, Focco van den Akker, and Robert A. Bonomo

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Voltage-Controlled Enzyme-Catalyzed Glucose–Gluconolactone Conversion Using A Field-Effect Enzymatic Detector, Siu Tung Yau, Yan Xu, Yang Song, Ye Feng, and Jiapeng Wang

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Bio-Inspired Liposomal Thrombomodulin Conjugate through Bio-Orthogonal Chemistry, Hailong Zhang, Jacob Weingart, Rui Jiang, Jianhao Peng, Qingyu Wu, and Xue-Long Sun

Submissions from 2012

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Exploring The Role of A Conserved Class A Residue in The Ω-Loop of KPC-2 β-Lactamase: A Mechanism For Ceftazidime Hydrolysis

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Understanding The Molecular Determinants of Substrate and Inhibitor Specificities in The Carbapenemase KPC-2: Exploring The Roles of Arg220 and Glu276

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Evaluating the Therapeutic Potential of A Non-Natural Nucleotide That Inhibits Human Ribonucleotide Reductase, Md. Faiz Ahmad, Qun Wan, Shalini Jha, Edward Motea, Anthony J. Berdis, and Chris Dealwis

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A Better Ion Fraction for a Neutral Aqueous Solution, David W. Ball

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Maxwell's Equations, Part V, David W. Ball

Maxwell's Equations, Part VI, David W. Ball

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Maxwell's Equations, Part VII, David W. Ball

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Quantities, Symbols, and Units in Spectroscopy, David W. Ball

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Structure and Thermodynamic Properties of Nitroformic Acid, Nitroformyl Nitrate, and Ammonium Nitroformate, David W. Ball

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Inhibiting Selective DNA Polymerases for Therapeutic Intervention, Anthony J. Berdis

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Removal of Uracil by Uracil DNA Glycosylase Limits Pemetrexed Cytotoxicity: Overriding the Limit with Methoxyamine to Inhibit Base Excision Repair, A. D. Bulgar, L. D. Weeks, Y. Miao, S. Yang, Yan Xu, C. Guo, S. Markowitz, N. Oleinick, S. L. Gerson, and Lili Liu

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Nucleoside Transporters: Biological Insights and Therapeutic Applications, Jung-Suk Choi and Anthony J. Berdis

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Gold-Containing Indoles as Anticancer Agents That Potentiate The Cytotoxic Effects of Ionizing Radiation, Sandra Craig, Lei Gao, Irene Lee, Thomas Gray, and Anthony J. Berdis

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Aminonitrocyclopropanes as Possible High-Energy Materials. Quantum Chemical Calculations, Joshua M. Halstead, Jessica N. Whittaker, and David W. Ball

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End-Point Immobilization of Recombinant Thrombomodulin via Sortase-Mediated Ligation, Rui Jiang, Jacob Weingart, Hailong Zhang, Yong Ma, and Xue-Long Sun

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BON-BONs: Cyclic Molecules with a Boron-Oxygen-Nitrogen Backbone. Computational Studies of Their Thermodynamic Properties, Aloysus K. Lawong and David W. Ball

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Introducing NOB-NOBs: nitrogen-oxygen-boron cycles with potential high-energy properties, Aloysus K. Lawong and David W. Ball

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Chemoselectively Surface Funtionalizable Tethered Bilayer Lipid Membrane for Versatile Membrane Mimetic Systems Fabrication, Yong Ma, Rui Jiang, Hailong Zhang, Valentinas Gruzdys, and Xue-Long Sun

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Liposomal Glyco-Microarray for Studying Glycolipid–Protein Interactions, Yong Ma, Irena Sobkiv, Valentinas Gruzdys, Hailong Zhang, and Xue-Long Sun

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A Non-Natural Nucleoside with Combined Therapeutic and Diagnostic Activities Against Leukemia, Edward A. Motea, Irene Lee, and Anthony J. Berdis

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Development of A ‘Clickable’ Non-Natural Nucleotide to Visualize The Replication of Non-Instructional DNA Lesions, Edward A. Motea, Irene Lee, and Anthony J. Berdis

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Quantitative Measurement of the Solvent Accessibility of Histidine Imidazole Groups in Proteins, Vennela Mullangi, Xiang Zhou, David W. Ball, David J. Anderson, and Masaru Miyagi

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Recent Advances in the Synthesis and Biomedical Applications of Chain-End Functionalized Glycopolymers, Satya Nandana Narla, Huan Nie, Yu Li, and Xue-Long Sun

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Glyco-Macroligand Microarray with Controlled Orientation and Glycan Density, Satya Nandana Narla and Xue-Long Sun

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Immobilized Sialyloligo-Macroligand and Its Proein Binding Specificity, Satya Nandana Narla and Xue-Long Sun

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Recent Advances in Sialic Acid-Focused Glycomics, Huan Nie, Yu Li, and Xue-Long Sun

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Synthesis of 1,3-Diphenyl-6-alkyl/aryl-Substituted Fulvene Chromophores: Observation of π–π Interactions in a 6-Pyrene-Substituted 1,3-Diphenylfulvene, Andrew J. Peloquin, Rebecca L. Stone, Sarah E. Avila, Erlyn R. Rudico, Christopher B. Horn, Kim A. Gardner, David W. Ball, Jane E.B. Johnson, Scott T. Iacono, and Gary J. Balaich

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Tissue Sample Preparation in Bioanalytical Assays, Kerri M. Smith and Yan Xu

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Solid-state Mechanical Properties of Crystalline Drugs and Excipients, Shravan Singh Thakur, Manik Pavan Kumar Maheswaram, Dhruthiman Reddy Mantheni, Lakshmi Kaza, Indika Perara, David W. Ball, John Moran, and Alan T. Riga

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Capillary Electrophoresis in Clinical Chemistry, Simuli L. Wabuyele and Yan Xu

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Development and Validation of An LC–MS/MS Method for Pharmacokinetic Study of Methoxyamine in Phase I Clinical Trial, Shuming Yang, Panayiotis Savvides, Lili Liu, Stanton L. Gerson, and Yan Xu

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Identification of A Class of Novel Tubulin Inhibitors, Xin Yi, Bo Zhong, Kerri M. Smith, Werner J. Geldenhuys, Ye Feng, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, and Bin Su

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Thermally-induced Dielectric Relaxation Spectra in Three Aldohexose Monosaccharides, Libby Yoerg, M. Ellen Matthews, Lakshmi Kaza, Naullage Indika Perera, David W. Ball, John Moran, and Alan T. Riga

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Carbohydrate-Protein Interactions and Their Biosensing Applications, Xiangqun Zeng, Cesar A.S. Andrade, Maria D.L. Oliveira, and Xue-Long Sun

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From COX-2 Inhibitor Nimesulide to Potent Anti-Cancer Agent: Synthesis, In Vitro, In Vivo and Pharmacokinetic Evaluation, Bo Zhong, Xiaohan Cai, Snigdha Chennamaneni, Xin Yi, Lili Liu, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, and Bin Su

Submissions from 2011

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Carbonyl Diazide, OC(N3)2: Calculated Thermodynamic Properties, David W. Ball

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Little Points of Light, David W. Ball

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Maxwell's Equations, Part I: History, David W. Ball

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Maxwell's Equations, Part II, David W. Ball

Maxwell's Equations, Part III, David W. Ball

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Maxwell's Equations, Part IV, David W. Ball

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Working Towards Greener High Energy Materials. DFT Calculations on Nitrated 3,6-Dihydro-1,2,4,5-tetrazine, Sara L. Brunswick and David W. Ball

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Exploring The Roles of Nucleobase Desolvation and Shape Complementarity During The Misreplication of O6-Methylguanine, Delia Chavarria, Andrea Ramos Serrano, Ichiro Hirao, and Anthony J. Berdis

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Active-Site-Directed Chemical Tools for Profiling Mitochondrial Lon Protease, Jennifer Fishovitz, Min Li, Hilary Frase, Jason Hudak, Sandra Craig, Kristin Ko, Anthony J. Berdis, Carolyn K. Suzuki, and Irene Lee

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The Exonuclease Activity of hPMC2 is Required for Transcriptional Regulation of The QR Gene and Repair of Estrogen-Induced Abasic Sites, N. Krishnamurthy, C. R. Ngam, Anthony J. Berdis, and M. M. Montano

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Azide-Reactive Liposome for Chemoselective and Biocompatible Liposomal Surface Functionalization and Glyco-Liposomal Microarray Fabrication, Yong Ma, Hailong Zhang, Valentinas Gruzdys, and Xue-Long Sun

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Quantifying the Energetic Contributions of Desolvation and π-Electron Density During Translesion DNA Synthesis, Edward A. Motea, Irene Lee, and Anthony J. Berdis

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Orientated Glyco-Macroligand Formation Based on Site-Specific Immobilization of O-Cyanate Chain-End Functionalized Glycopolymer, Satya Nandana Narla and Xue-Long Sun

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Glycosylation and Processing of Pro-B-Type Natriuretic Peptide in Cardiomyocytes, Jianhao Peng, Jingjing Jiang, Wei Wang, Xiaofei Qi, Xue-Long Sun, and Qingyu Wua

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Epistatic Roles for Pseudomonas Aeruginosa MutS and DinB (DNA Pol IV) in Coping with Reactive Oxygen Species-Induced DNA Damage, Laurie H. Sanders, Babho Devadoss, Geraldine V. Raja, Jaime O'Connor, Shengchang Su, Daniel J. Wozniak, Daniel J. Hassett, Anthony J. Berdis, and Mark D. Sutton

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Determination of Hexamethylene Bisacetamide, An Antineoplastic Compound, in Mouse and Human Plasma by LC–MS/MS, Kerri M. Smith, Wannarasmi Ketchart, Xiang Zhou, Monica M. Montano, and Yan Xu

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Nitrospiropentanes as Potential High Energy Materials, Rachelle R. Wagner and David W. Ball

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Towards New Green High Energy Materials. Computational Chemistry on Nitro-Substituted Urea, Rachelle R. Wagner and David W. Ball