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Submissions from 2017

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A Dilute-and-Shoot Flow-Injection Tandem Mass Spectrometry Method for Quantification of Phenobarbital in Urine, Ravali Alagandula, Xiang Zhou, and Baochuan Guo

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Straightforward Synthesis of N-Glycan Polymers from Free Glycans via Cyanoxyl Free Radical-Mediated Polymerization, Jinshan Tang, Evgeny Ozhegov, Yang Liu, Dan Wang, Xinsheng Yao, and Xue-Long Sun

Submissions from 2016

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Electrons as “Agents” and “Signals” of Change in Organic Chemistry, Biology, and Beyond, Mekki Bayachou and James Burgess

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Indomethacin Derivatives as Tubulin Stabilizers to Inhibit Cancer Cell Proliferation, Snigdha Chennamaneni, Chunfang Gan, Rati Lama, Bo Zhong, and Bin Su

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Chapter 7 – Chemotherapeutic Intervention by Inhibiting DNA Polymerases, A. Dasari, Jung-Suk Choi, and Anthony J. Berdis

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Synthesis, Electrochemical Characterization, and Linear Free Energy Relationship of 1,3-Diphenyl-6-alkyl/arylfulvenes, Nicholas P. Godman, Sonya K. Adas, Karl M. Hellwig, David W. Ball, Gary J. Balaich, and Scott T. Iacono

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Structural Insights Into High Density Lipoprotein: Old Models and New Facts, Valentin Gogonea

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Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction, Xiaodong Gu, Ying Huang, Bruce S. Levison, Gary Gerstenecker, Anthony J. DiDonato, Leah B. Hazen, Joonsue Lee, Valentin Gogonea, Joseph A. DiDonato, and Stanley L. Hazen

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A Systematic Investigation of Structure/Function Requirements for The Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein, Xiaodong Gu, Zhiping Wu, Ying Huang, Matthew A. Wagner, Camelia Baleanu Gogonea, Ryan A. Mehl, Jennifer A. Buffa, Anthony J. DiDonato, Leah B. Hazen, Paul L. Fox, Valentin Gogonea, John S. Parks, Joseph A. DiDonato, and Stanley L. Hazen

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Oncogenic PIK3CA Mutations Reprogram Glutamine Metabolism in Colorectal Cancer, Yujun Hao, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, Bohan Dong, Bo Cao, Xiujing Feng, Min Xiang, Claire Xu, Stephen Fink, Neal J. Meropol, and Yan Xu

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Quantification of Monosialogangliosides in Human Plasma Through Chemical Derivatization for Signal Enhancement in LC–ESI-MS, Qianyang Huang, Danting Liu, Baozhong Xin, Karen Cechner, Xiang Zhou, Heng Wang, and Aimin Zhou

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Determination of MLN0128, An Investigational Antineoplastic Agent, in Human Plasma by LC–MS/MS, Sandeep R. Kunati and Yan Xu

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Measurement of Ring Strain Using Butanols: A Physical Chemistry Lab Experiment, William R. Martin, Ada S. Davidson, and David W. Ball

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Preparation and Structures of Two Mixed-Ligand 4-methylpyridine Indium Bromide Complexes, John Masnovi, Eric B. Clark, Aloysius F. Hepp, John D. Schupp, and Philip E. Fanwick

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Inhibition of Yeast Ribonucleotide Reductase by Sml1 Depends on the Allosteric State of the Enzyme, Tessianna A. Misko, Sanath R. Wijerathna, Tomas Radivoyevitch, Anthony J. Berdis, Md. Faiz Ahmad, Michael E. Harris, and Chris G. Dealwis

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Orally Active and Selective Tubulin Inhibitors as Anti-Trypanosome Agents, Vishal Nanavaty, Rati Lama, Ranjodh Sandhu, Bo Zhong, Daniel Kulman, Viharika Bobba, Anran Zhao, Bibo Li, and Bin Su

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Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function, Yana Sandlers, Kelly Mercier, Wimal Pathmasiri, Jim Carlson, Susan McRitchie, Susan Sumner, and Hilary J. Vernon

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Sialylation and Desialylation Dynamics of Monocytes Upon Differentiation and Polarization to Macrophages, Dan Wang, Evgeny Ozhegov, Lin Wang, Aimin Zhou, Huan Nie, Yu Li, and Xue Long Sun

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Early Growth and Development Impairments in Patients with Ganglioside GM3 Synthase Deficiency, H. Wang, A. Wang, Dan Wang, A. Bright, V. Sency, Aimin Zhou, and B. Xin

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Preparation of Chain-End Clickable Recombinant Protein and its Bio-Orthogonal Modification, Lin Wang, Rui Jiang, Lin Wang, Yang Liu, and Xue-Long Sun

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TMCO1 Is An ER Ca2+ Load-Activated Ca2+ Channel, Qiao Chu Wang, Qiaoxia Zheng, Haiyan Tan, Bing Zhang, Xiaoling Li, Yuxiu Yang, Jie Yu, Yang Liu, Hao Chai, Xi Wang, Zhongshuai Sun, Jiu Qiang Wang, Shu Zhu, Fengli Wang, Maojun Yang, Caixia Guo, Heng Wang, Qingyin Zheng, Yang Li, Quan Chen, Aimin Zhou, and Tie Shan Tang

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The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin, Joesph R. Wiencek, Jamila Hirbawi, Vivien C. Yee, and Michael Kalafatis

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Synthesis of an End-to-End Protein–Glycopolymer Conjugate via Bio-Orthogonal Chemistry, Hailong Zhang, Jacob Weingart, Valentinas Gruzdys, and Xue-Long Sun

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Targeting Radioresistant Breast Cancer Cells by Single Agent CHK1 Inhibitor via Enhancing Replication Stress, Yao Zhang, Jinzhi Lai, Zhanwen Du, Jinnan Gao, Shuming Yang, Shashank Gorityala, Xiahui Xiong, Ou Deng, Zhefu Ma, Chunhong Yan, Gonzalo Susana, Yan Xu, and Junran Zhang

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Structural Optimization of Non-Nucleoside DNA Methyltransferase Inhibitor as Anti-Cancer Agent, Bo Zhong, Sergei Vatolin, Nethrie D. Idippily, Rati Lama, Laila A. Alhadad, Frederic J. Reu, and Bin Su

Submissions from 2015

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Determination of Triapine, A Ribonucleotide Reductase Inhibitor, In Human Plasma by Liquid Chromatography Tandem Mass Spectrometry, Ye Feng, Charles A. Kunos, and Yan Xu

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In Vitro and In Vivo Evaluation of Tubulin Inhibitors with Non-Small Cell Lung Cancer Pre-Clinical Models, Rati Lama, Danting Liu, Bo Zhong, David Danielpour, Aimin Zhou, and Bin Su

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Structural Characterization of Copper–Indium Chalcopyrite Precursors (PPh3)2CuIn(ER)4 [R=CH3, E=S and R=Ph, E=S and Se], John Masnovi, Kulbinder K. Banger, Philip E. Fanwick, and Aloysius F. Hepp

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Aminonitronaphthalenes as Possible High Energy Density Materials, Rebecca J. Murawski and David W. Ball

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Oriented Immobilized Sialyloligo-macroligand Microarray, Satya Nandana Narla and Xue-Long Sun

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Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyltransferases-IVa Regulation, Huan Nie, Xia Liu, Yubao Zhang, Tingting Li, Chao Zhan, Wenjuan Huo, Anshun He, Yuanfei Yao, Yu Jin, Youpeng Qu, Xue-Long Sun, and Yu Li

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DFT/QTAIM Analysis of the Effect of Late Transition Metal Doping on Methane Selectivity in Fischer–Tröpsch Catalysis, Peter C. Psarras and David W. Ball

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Effects of Interferons and Double-Stranded RNA on Human Prostate Cancer Cell Apoptosis, Haiyan Tan, Chun Zeng, Junbo Xie, Norah J. Alghamdi, Ya Song, Hongbing Zhang, Aimin Zhou, and Di Jin

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A Rapid LC-MS/MS Method for Quantification of CSUOH0901, A Novel Antitumor Agent, in Rat Plasma, Ramakrishna R. Voggu, Ravali Alagandula, Xiang Zhou, Bin Su, Bo Zhong, and Baochuan Guo

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A Simple and Rapid LC-MS/MS Method for The Determination of BMCL26 A Novel Anti-Parasitic Agent in Rat Plasma, Ramakrishna R. Voggu, Xiang Zhou, Bing Su, and Baochuan Guo

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Globally Profiling Sialylation Status of Macrophages Upon Statin Treatment, Dan Wang, Huan Nie, Evgeny Ozhegov, Lin Wang, Aimin Zhou, Yu Li, and Xue Long Sun

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Glyco-Functionalized Liposomes, Jacob J. Weingart, Pratima Vabbilisetty, and Xue-Long Sun

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Synthesis and Biological Evaluation of Thiabendazole Derivatives as Anti-Angiogenesis and Vascular Disrupting Agents, Chao Zhang, Bo Zhong, Simin Yang, Liangkun Pan, Siwang Yu, Zhongjun Li, Shuchun Li, Bin Su, and Xiangbao Meng

Submissions from 2014

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P101 – Endothelial Nitric Oxide Synthase (eNOS) on Lipid Nanodiscs: Toward A Soluble Assembly Reflecting Native-Like Function of eNOS, Ghaith Altawallbeh, Chris Verdi, Mohammad Mahfuzul Haque, Dennis Stuehr, and Mekki Bayachou

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Cryoprotective Effect of l-Carnitine on Motility, Vitality and DNA Oxidation of Human Spermatozoa, S. Banihani, A. Agarwal, R. Sharma, and Mekki Bayachou

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P105 – Enzyme-Based Nitric Oxide Releasing Thin Films and Fibers, Mekki Bayachou, Bhagya Gunesekera, and Gary Wnek

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Site-Specific Nitration of Apolipoprotein A-I at Tyrosine 166 Is Both Abundant within Human Atherosclerotic Plaque and Dysfunctional, Joseph A. DiDonato, Kulwant Aulak, Ying Huang, Matthew A. Wagner, Gary Gerstenecker, Celalettin Topbas, Valentin Gogonea, Anthony J. DiDonato, W.H. Wilson Tang, Ryan A. Mehl, Paul L. Fox, Edward F. Plow, Jonathan D. Smith, Edward A. Fisher, and Stanley L. Hazen

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Development of A Liquid Chromatographic Method for Quantitative Determination of Triapine, A Ribonucleotide Reductase Inhibitor, by Spectrophotometric Study of Triapine Complexation Reaction, Ye Feng, Melissa McCulloch, and Yan Xu

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Distinct Conformational Behaviors of Four Mammalian Dual-Flavin Reductases (Cytochrome P450 Reductase, Methionine Synthase Reductase, Neuronal Nitric Oxide Synthase, Endothelial Nitric Oxide Synthase) Determine Their Unique Catalytic Profiles, Mohammad Mahfuzul Haque, Mekki Bayachou, Jesus Tejero, Claire T. Kenney, Naw M. Pearl, Sang-Choul Im, Lucy Waskell, and Dennis J. Stuehr

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Oral 1832-2 – Charge Pairing and Phosphorylation Regulate The Conformational Equilibrium and Switching Rates in Neuronal and Endothelial NO Synthase Flavoprotein Domains, Mohammad Mahfuzul Haque, Sougata Sinha Ray, Mekki Bayachou, and Dennis Stuehr

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A New Liquid Chromatography/Tandem Mass Spectrometry Method for Quantification of Gangliosides in Human Plasma, Qianyang Huang, Xiang Zhou, Danting Liu, Baozhong Xin, Karen Cechner, Heng Wang, and Aimin Zhou

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Synthesis and Evaluation of Some New Aza-B-Homocholestane Derivatives as Anticancer Agents, Yanmin Huang, Jianguo Cui, Sijing Chen, Qifu Lin, Huacan Song, Chunfang Gan, Bin Su, and Aimin Zhou

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An Abundant Dysfunctional Apolipoprotein A1 in Human Atheroma, Ying Huang, Joseph A. DiDonato, Bruce S. Levison, Dave Schmitt, Lin Li, Yuping Wu, Jennifer Buffa, Timothy Kim, Gary S. Gerstenecker, Xiaodong Gu, Chandra S. Kadiyala, Zeneng Wang, Miranda K. Culley, Jennie E. Hazen, Anthony J. DiDonato, Xiaoming Fu, Stela Z. Berisha, Daoquan Peng, Truc T. Nguyen, Shaohong Liang, Chia-Chi Chuang, Leslie Cho, Edward F. Plow, Paul L. Fox, Valentin Gogonea, W.H. Wilson Tang, John S. Parks, Edward A. Fisher, Jonathan D. Smith, and Stanley L. Hazen

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P142 – Graphene-Based Nanostructured Interfaces for Selective and Sensitive Peroxynitrite Detection, Haitham Kalil and Mekki Bayachou

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Bioassay Guided Identification of Small Chaperone Proteins α-crystallin and Hsp27 Inhibitors from Copaiba Oil, Rati Lama, Bo Zhong, Daniel G. Kulman, and Bin Su Ph.D.

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A Kinetic Analysis of The Inhibition of FOX-4 β-Lactamase, A Plasmid-Mediated AmpC Cephalosporinase, By Monocyclic β-lactams and Carbapenems, Krisztina M. Papp-Wallace, Susana Mallo, Christopher R. Bethel, Magdalena A. Taracila, Andrea M. Hujer, Ana Fernandez, Julian A. Gatta, Kerri M. Smith, Yan Xu, Malcolm G.P. Page, Eric Desarbre, German Bou, and Robert A. Bonomo

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Reclaiming The Efficacy of β-Lactam–β-Lactamase Inhibitor Combinations: Avibactam Restores The Susceptibility of CMY-2-Producing Escherichia Coli to Ceftazidime, Krisztina M. Papp-Wallace, Marisa L. Winkler, Julian A. Gatta, Magdalena A. Taracila, Sujatha Chilakala, Yan Xu, J. Kristie Johnson, and Robert A. Bonomo

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P197 – Sensitive and Selective Electrochemical NO Sensors Modified with Nanostructured Catalyst: Towards Probing The Role of NO in Cystic Fibrosis Pathophysiology, Bose Tiyash, Thomas Bomberger, and Mekki Bayachou

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Liposome Surface Functionalization Based on Different Anchoring Lipids via Staudinger Ligation, Pratima Vabbilisetty and Xue-Long Sun

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Development and Validation of LC–MS/MS Method for Quantitative Determination of (−)-Securinine in Mouse Plasma, Simuli L. Wabuyele, David Wald, and Yan Xu

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Mediatorless Immunoassay with Voltage-Controlled Intrinsic Amplification for Ultrasensitive and Rapid Detection of Microorganism Pathogens, Jiapeng Wang, Yan Xu, and Siu Tang Yau

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Systematic Investigation of Quinoxaline Derivatization of Sialic Acids and Their Quantitation Applicability Using High Performance Liquid Chromatography, Libo Wang, Dan Wang, Xiang Zhou, Lijun Wu, and Xue-Long Sun

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Primary Arylamine-based Tyrosine-targeted Protein Modification, Lin Wang, Valentinas Gruzdys, Nan Pang, Fanhao Meng, and Xue-Long Sun

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RNase L Contributes to Experimentally Induced Type 1 Diabetes Onset in Mice, Chun Zeng, Xin Yi, Danny Zipris, Hongli Liu, Lin Zhang, Qiaoyun Zheng, Krishnamurthy Malathi, Ge Jin, and Aimin Zhou

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Lead Optimization of HMBA to Develop Potent HEXIM1 Inducers, Bo Zhong, Rati Lama, Wannarasmi Ketchart, Monica M. Montano, and Bin Su

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Lead Optimization of Dual Tubulin and Hsp27 Inhibitors, Bo Zhong, Rati Lama, Daniel G. Kulman, Bibo Li Ph.D., and Bin Su Ph.D.

Submissions from 2013

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Logger Rhythm, David W. Ball

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Wien’s Displacement Law as a Function of Frequency, David W. Ball

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Spectroscopic Analysis of Polymerization and Exonuclease Proofreading By A High-Fidelity DNA Polymerase During Translesion DNA Synthesis, Babho Devadoss, Irene Lee, and Anthony J. Berdis

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Function and Distribution of Apolipoprotein A1 in The Artery Wall Are Markedly Distinct From Those in Plasma, Joseph A. DiDonato, Ying Huang, Kulwant S. Aulak, Orli Even-Or, Gary Gerstenecker, Valentin Gogonea, Yuping Wu, Paul L. Fox, W.H. Wilson Tang, Edward F. Plow, Jonathan D. Smith, Edward A. Fisher, and Stanley L. Hazen

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The Low-Resolution Structure of Nascent High Density Lipoprotein Reconstituted with DMPC With and Without Cholesterol Reveals A Mechanism for Particle Expansion, Valentin Gogonea, Gary S. Gerstenecker, Zhiping Wu, Xavier Lee, Celalettin Topbas, Matthew A. Wagner, Thomas C. Tallant, Jonathan D. Smith, Phil Callow, Vitaliy Pipich, Helen Malet, Guy Schoehn, Joseph A. DiDonato, and Stanley L. Hazen

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Development and Characterization of A Non-natural Nucleoside that Displays Anticancer Activity Against Solid Tumors, Jackelyn Golden, Edward A. Motea, Xuemei Zhang, Jung-Suk Choi, Ye Feng, Yan Xu, Irene Lee, and Anthony J. Berdis

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A Phase 1 Study of TRC102, An Inhibitor of Base Excision Repair, and Pemetrexed in Patients with Advanced Solid Tumors, Michael S. Gordon, Lee S. Rosen, David Mendelson, Ramesh K. Ramanathan, Jonathan Goldman, Lili Liu, Yan Xu, Stanton L. Gerson, Stephen P. Anthony, William D. Figg, Shawn Spencer, Bonne J. Adams, Charles P. Theuer, Bryan R. Leigh, and Glen J. Weiss

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Charge-Pairing Interactions Control The Conformational Setpoint and Motions of The FMN Domain in Neuronal Nitric Oxide Synthase, Mohammad Mahfuzul Haque, Mekki Bayachou, Mohammed A. Fadlalla, Deborah Durra, and Dennis J. Stuehr

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Thermodynamic Characterization of Five Key Kinetic Parameters That Define Neuronal Nitric Oxide Synthase Catalysis, Mohammad Mahfuzul Haque, Jesus Tejero, Mekki Bayachou, Zhi-Qiang Wang, Mohammed Fadlalla, and Dennis J. Stuehr

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Synthesis and Evaluation of Some 17-Acetamidoandrostane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity Studies, Yanmin Huang, Jianguo Cui, Linyi Jia, Chunfang Gan, Huacan Song, Chun Zeng, and Aimin Zhou

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Myeloperoxidase, Paraoxonase-1, and HDL Form A Functional Ternary Complex, Ying Huang, Zhiping Wu, Meliana Riwanto, Shengqiang Gao, Bruce S. Levison, Xiaodong Gu, Xiaoming Fu, Matthew A. Wagner, Christian Besler, Gary Gerstenecker, Renliang Zhang, Xin Min Li, Anthony J. DiDonato, Valentin Gogonea, W.H. Wilson Tang, Jonathan D. Smith, Edward F. Plow, Paul L. Fox, Diana M. Shih, Aldons J. Lusis, Edward A. Fisher, Joseph A. DiDonato, Ulf Landmesser, and Stanley L. Hazen

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Inhibition of Metastasis by HEXIM1 Through Effects on Cell Invasion and Angiogenesis, W. Ketchart, Kerri M. Smith, T. Krupka, B. M. Wittmann, Y. Hu, P. A. Rayman, Y. Q. Doughman, J. M. Albert, X. Bai, J. H. Finke, Yan Xu, A. A. Exner, and M. M. Montano

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Can Inhibitor-Resistant Substitutions in The Mycobacterium Tuberculosis β-Lactamase BlaC Lead to Clavulanate Resistance?: A Biochemical Rationale for The Use of β-Lactam–β-Lactamase Inhibitor Combinations, Sebastian G. Kurz, Kerstin A. Wolff, Saugata Hazra, Christopher R. Bethel, Andrea M. Hujer, Kerri M. Smith, Yan Xu, Lee W. Tremblay, John S. Blanchard, Liem Nguyen, and Robert A. Bonomo

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Development, Validation and Pilot Screening of An In Vitro Multi-Cellular Three-Dimensional Cancer Spheroid Assay for Anti-Cancer Drug Testing, Rati Lama, Lin Zhang, Janine M. Naim, Jennifer Williams, Aimin Zhou, and Bin Su

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A Comparative Study of Antitumor Activities and DNA Cleavage On A Class of Dehydroabietylamine Derivatives, Chao Xiang Liu, Zhong Xiang Lin, Xing Yu, Zhou Lu, Aimin Zhou, and Yong Li Bao

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Why is the Sky Blue?, James A. Locke and David W. Ball

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Cyclometalated Iridium(III) Complexes with Deoxyribose Substituents, Ayan Maity, Jung-Suk Choi, Thomas S. Teets, Nihal Deligonul, Anthony J. Berdis, and Thomas G. Gray

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Metastable Nanostructured Metallized Fluoropolymer Composites for Energetics, Hannah A. Miller, Bradley S. Kusel, Seth T. Danielson, James W. Neat, Eryn K. Avjian, Scott N. Pierson, Stephen M. Budy, David W. Ball, Scott T. Iacono, and Sharon C. Kettwich

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Insights Into The Roles of Desolvation and π-Electron Interactions During DNA Polymerization, Edward A. Motea, Irene Lee, and Anthony J. Berdis

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Peroxynitrite Activity of Hemin-Functionalized Reduced Graphene Oxide, Raluca Oprea, Serban F. Peteu, Palaniappan Subramanian, Wang Qi, Emmanualle Pichonat, Henri Happy, Mekki Bayachou, Rabah Boukherroub, and Sabine Szunerits

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Polymerized Hemin as An Electrocatalytic Platform for Peroxynitrite's Oxidation and Detection, Serban F. Peteu, Tiyash Bose, and Mekki Bayachou

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β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of An Unprecedented Stabilized Acyl-Enzyme, Elizabeth A. Rodkey, David C. Mcleod, Christopher R. Bethel, Kerri M. Smith, Yan Xu, Weirui Chai, Tao Che, Paul R. Carey, Robert A. Bonomo, Focco van den Akker, and John D. Buynak

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Membrane Mimetic Surface Functionalization of Nanoparticles: Methods and Applications, Jacob Weingart, Pratima Vabbilisetty, and Xue-Long Sun

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Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with A Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase, Marisa L. Winkler, Elizabeth A. Rodkey, Magdalena A. Taracila, Sarah M. Drawz, Christopher R. Bethel, Krisztina M. Papp-Wallace, Kerri M. Smith, Yan Xu, Jeffrey R. Dwulit-Smith, Chiara Romagnoli, Emilia Caselli, Fabio Prati, Focco van den Akker, and Robert A. Bonomo

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Voltage-Controlled Enzyme-Catalyzed Glucose–Gluconolactone Conversion Using A Field-Effect Enzymatic Detector, Siu Tung Yau, Yan Xu, Yang Song, Ye Feng, and Jiapeng Wang

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Lack of RNase L Attenuates Macrophage Functions, Xin Yi, Chun Zeng, Hongli Liu, Xiaoli Chen, Ping Zhang, Boo Seok Yun, Ge Jin, and Aimin Zhou

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Bio-Inspired Liposomal Thrombomodulin Conjugate through Bio-Orthogonal Chemistry, Hailong Zhang, Jacob Weingart, Rui Jiang, Jianhao Peng, Qingyu Wu, and Xue-Long Sun

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Synthesis and Anticancer Mechanism Investigation of Dual Hsp27 and Tubulin Inhibitors, Bo Zhong, Snigdha Chennamaneni, Rati Lama, Xin Yi, Werner J. Geldenhuys, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, and Bin Su Ph.D.

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Synthesis and Anticancer Mechanism Investigation of Dual Hsp27 and Tubulin Inhibitors, Bo Zhong, Snigdha Chennamaneni, Rati Lama, Xin Yi, Werner J. Geldenhuys, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, and Bin Su