Title

Screw-Cap Clamp Loader Proteins that Thread

Document Type

Article

Publication Date

2004

Publication Title

Nature Structural and Molecular Bology

Abstract

Structures of the clamp loader–clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication.

DOI

10.1038/nsmb0704-580

Volume

11