Title

Direct Electron Transfer to The Oxygenase Domain of Neuronal Nitric Oxide Synthase (NOS): Exploring Unique Redox Properties of NOS Enzymes

Document Type

Article

Publication Date

10-13-2004

Publication Title

Journal of The American Chemical Society

Abstract

Thin film direct electrochemistry shows that the oxygenase domain of neuronal nitric oxide synthase undergoes reversible electron transfer with an underlying electrode. The midpotential of the FeIII/FeII couple is found to be modulated by both the binding of the tetrahydropterin cofactor and the pH of the buffer medium.

Comments

This research is supported by the U.S. DOE-BES through a grant of the “ Catalysis Science ” program to M.B. (DE- FG02-03ER15462).

DOI

10.1021/ja0482987

Volume

126

Issue

40