Document Type

Article

Publication Date

3-1-2008

Publication Title

The Journal of Steroid Biochemistry and Molecular Biology

Abstract

Recent studies exhibit that 4-hydroxyphenylretinamide (4HPR) decreases aromatase activity in breast and placental cells. The effect of synthetic 4HPR analogs on aromatase and expression was examined in three breast cancer cell lines. Most derivatives did not decrease cellular aromatase activity. Two of the analogs even stimulated aromatase activity at the transcriptional level. Only one derivative significantly decreased aromatase in all three breast cancer cell lines and also suppressed CYP19 gene expression in one of the cell line. Placental microsomal aromatase assay rule out the possibility that this compound directly inhibits the aromatase enzyme. A non-genomic mechanism in suppression of cellular aromatase activity of this compound is proposed.

Comments

This work was supported by the National Institutes of Health (NIH) Grant R01 CA73698 (to R.W.B.), CA49837 (to R.W.C., Jr.), and The Ohio State University Comprehensive Cancer Center Breast Cancer Research Fund.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

DOI

10.1016/j.jsbmb.2007.12.005

Version

Postprint

Volume

109

Issue

2017-01-02

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