Document Type

Article

Publication Date

7-1-2012

Publication Title

Steroids

Abstract

Here we report that 6-hydroximino-4-aza-A-homo-cholest-3-one and 6-hydroxyl-4-aza-A-homo-cholest-3-one, new steroidal lactams were synthesized recently, displayed antiproliferative activity against some cancer cells through inducing cancer cell apoptosis by activation of the intrinsic pathway. The apoptotic function of the compounds was demonstrated by release of cytochrome C, activation of caspase 3 and annexin V labeling. Furthermore, the compound was able to inhibit tumor growth in an athymic mouse model.

Comments

The authors acknowledge the financial support of the Natural Science Foundation of Guangxi Province, P.R. of China. (No: 2010GXNSFD013019).

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

DOI

10.1016/j.steroids.2012.04.016

Version

Postprint

Volume

77

Issue

2017-08-09

Included in

Chemistry Commons

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