Document Type

Article

Publication Date

12-1-2009

Publication Title

Bioorganic & Medicinal Chemistry Letters

Abstract

A series of COX-2 selective inhibitor nimesulide derivatives were synthesized. Their anti-cell proliferation activities were evaluated with a long-term estrogen deprived MCF-7aro (LTEDaro) breast cancer cell line, which is the biological model of aromatase inhibitor resistance for hormone-dependent breast cancer. Compared to nimesulide which inhibited LTEDaro cell proliferation with an IC50 at 170.30 μM, several new compounds showed IC50 close to 1.0 μM.

Comments

This work was supported by grants from the National Institutes of HealthCA44735 (S.C.), ES08528 (S.C.).

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

DOI

10.1016/j.bmcl.2009.09.109

Version

Postprint

Volume

19

Issue

23

Included in

Chemistry Commons

Share

COinS