Document Type
Article
Publication Date
1-1-2009
Publication Title
Steroids
Abstract
The side chain of a compound plays an important role in its biological function. In our studies, we have found that hydroximinosteroid derivatives with different side chains and position of hydroximino on ring A and B displayed remarkable distinct cytotoxicities against a diversity of cancer cell types. Presence of an oxime group on ring B and a hydroxy on ring A or B resulted in a higher cytotoxicity than other structural motifs. In addition, a cholesterol-type side chain at position 17 was required for the biological activity. Our findings provide new evidence showing the relationship between the chemical structure and biological function. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.
Recommended Citation
Cui, Jianguo; Fan, Lei; Huang, Li Liang; Liu, Hong Li; and Zhou, Aimin, "Synthesis and Evaluation of Some Steroidal Oximes as Cytotoxic Agents: Structure/Activity Studies (I)" (2009). Chemistry Faculty Publications. 417.
https://engagedscholarship.csuohio.edu/scichem_facpub/417
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
10.1016/j.steroids.2008.09.003
Version
Postprint
Volume
74
Issue
1
Comments
The authors acknowledge the financial support of the National Natural Science Foundation of China (Project: 20562001), the Natural Science Foundation of Guangxi Province (Guike: 057554).