Document Type

Article

Publication Date

1-1-2009

Publication Title

Steroids

Abstract

The side chain of a compound plays an important role in its biological function. In our studies, we have found that hydroximinosteroid derivatives with different side chains and position of hydroximino on ring A and B displayed remarkable distinct cytotoxicities against a diversity of cancer cell types. Presence of an oxime group on ring B and a hydroxy on ring A or B resulted in a higher cytotoxicity than other structural motifs. In addition, a cholesterol-type side chain at position 17 was required for the biological activity. Our findings provide new evidence showing the relationship between the chemical structure and biological function. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.

Comments

The authors acknowledge the financial support of the National Natural Science Foundation of China (Project: 20562001), the Natural Science Foundation of Guangxi Province (Guike: 057554).

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

DOI

10.1016/j.steroids.2008.09.003

Version

Postprint

Volume

74

Issue

1

Included in

Chemistry Commons

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