On the Mechanism of Condensation between 5-Amino-4, 6-dichloro- 2-methylpyrimidine and 1-Acetyl-2-imidazolin-2-one

Authors

Bin Su, Cleveland State UniversityFollow
Hui Li, Peking University
Meng Shen Cai, Peking University
Zhong Jun Li, Peking University

Document Type

Article

Publication Date

3-1-2002

Publication Title

Chinese Chemical Letters

Abstract

The condensation reaction between 5-amino-4, 6-dichloro-2-methylpyrimidine and 1-acetyl-2-imidazolin-2-one using POCl3 as solvent gave 4, 6-dichloro-2-methyl-5-(1-acetyl-tetra-hydro-imidazo-2-ylidene)- aminopyrimidine predominantly and 4, 6-dichloro-2-methyl-5-{1-[1-(2-oxo-tetrahydro-imidazolyl)]-acetyene}- aminopyrimidine as by-product. No 4, 6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine was found. The result indicated an esterifi- cation-addition-elimination mechanism.

Recommended Citation

Su, Bin; Li, Hui; Cai, Meng Shen; and Li, Zhong Jun, "On the Mechanism of Condensation between 5-Amino-4, 6-dichloro- 2-methylpyrimidine and 1-Acetyl-2-imidazolin-2-one" (2002). Chemistry Faculty Publications. 440.
https://engagedscholarship.csuohio.edu/scichem_facpub/440

Volume

13

Issue

3