Title

Xanthones From The Botanical Dietary Supplement Mangosteen (Garcinia mangostana) with Aromatase Inhibitory Activity

Document Type

Article

Publication Date

7-1-2008

Publication Title

Journal of Natural Products

Abstract

Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay. Of these compounds, garcinone D (3), garcinone E (5), α-mangostin (8), and γ-mangostin (9) exhibited dose-dependent inhibitory activity. In a follow-up cell-based assay using SK-BR-3 breast cancer cells that express high levels of aromatase, the most potent of these four xanthones was γ-mangostin (9). Because xanthones may be consumed in substantial amounts from commercially available mangosteen products, the consequences of frequent intake of mangosteen botanical dietary supplements require further investigation to determine their possible role in breast cancer chemoprevention.

Comments

We are grateful for financial support through a University Fellowship and a Dean’s Scholar Award from the Graduate College of the University of Illinois at Chicago, awarded to M.J.B. Other support was provided by NIH grant R01 CA73698 (P.I., R.W.B.), The Ohio State University Comprehensive Cancer Center (OSUCCC) Breast Cancer Research Fund (to R.W.B.), and the OSUCCC Molecular Carcinogenesis and Chemoprevention Program (to A.D.K.).

DOI

10.1021/np8000255

Volume

71

Issue

7