Title

Chemically-Selective Surface Glyco-Functionalization of Liposomes Through Staudinger Ligation

Document Type

Article

Publication Date

5-22-2009

Publication Title

Chemical Communications

Abstract

An efficient and chemoselective liposome surface glyco-functionalization method has been developed based on Staudinger ligation, in which the carbohydrate derivative carrying an azide spacer is conjugated onto the surface of preformed liposomes bearing a terminal triphosphine in PBS buffer (pH 7.4) at room temperature.

Comments

The authors acknowledge financial support under grants from American Health Assistance Foundation (AHAF-H2007027) and the Startup Fund from Cleveland State University.

DOI

10.1039/b822420j

Issue

21