Title

Recent Developments in Carbohydrate-Decorated Targeted Drug/Gene Delivery

Document Type

Article

Publication Date

3-2010

Publication Title

Medicinal Research Reviews

Abstract

Targeted delivery of a drug or gene to its site of action has clear therapeutic advantages by maximizing its therapeutic efficiency and minimizing its systemic toxicity. Generally, targeted drug or gene delivery is performed by loading a macromolecular carrier with an appropriate drug or gene, and by targeting the drug/gene carrier to specific cell or tissue with the help of specific targeting ligand. The emergence of glycobiology, glycotechnology, and glycomics and their continual adaptation by pharmaceutical scientists have opened exciting avenue of medicinal applications of carbohydrates. Among them, the biocompatibility and specific receptor recognition ability confer the ability of carbohydrates as potential targeting ligands for targeted drug and gene delivery applications. This review summarizes recent progress of carbohydrate-decorated targeted drug/gene delivery applications. © 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 2, 270–289, 2010

Comments

Contract grant sponsor: American Heart Association; Contract grant number: AHA-0565287B; Contract grant sponsor: American Health Assistance Foundation; Contract grant number: AHAF-H2007027; Contract grant sponsor: Cleveland State
University Startup Fund.

DOI

10.1002/med.20171

Volume

30

Issue

2