Tissue Engineering Approaches for Motor Neuron Pathway Regeneration
Journal of Regenerative Medicine
During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.
Farrell, Kurt and Kothapalli, Chandrasekhar R., "Tissue Engineering Approaches for Motor Neuron Pathway Regeneration" (2012). Chemical & Biomedical Engineering Faculty Publications. 188.
Farrell K, Kothapalli CR (2012) Tissue Engineering Approaches for Motor Neuron Pathway Regeneration. J Regen Med 1:2. doi:10.4172/2325-9620.1000102