Document Type

Article

Publication Date

9-10-2019

Publication Title

ACS Omega

Abstract

The cobalt(II) complex salts [Co(bpy)(az)2](PF6)2 and [Co(az)4](PF6), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

Comments

K.A.E. was supported by a Graduate Student Research Award from Cleveland State University. A.Z. was supported by a Gene Regulation in Health and Disease (GRHD) Award from Cleveland State University.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

DOI

10.1021/acsomega.9b01684

Version

Publisher's PDF

Volume

4

Issue

11

Included in

Chemistry Commons

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