Document Type
Article
Publication Date
2020
Publication Title
Mathematical Biosciences and Engineering
Abstract
Kidney tubules are lined with flow-sensing structures, yet information about the flow itself is not easily obtained. We aim to generate a multiscale biomechanical model for analyzing fluid flow and fluid-structure interactions within an elastic kidney tubule when the driving pressure is pulsatile. We developed a two-dimensional macroscopic mathematical model of a single fluid-filled tubule corresponding to a distal nephron segment and determined both flow dynamics and wall strains over a range of driving frequencies and wall compliances using finite-element analysis. The results presented here demonstrate good agreement with available analytical solutions and form a foundation for future inclusion of elastohydrodynamic coupling by neighboring tubules. Overall, we are interested in exploring the idea of dynamic pathology to better understand the progression of chronic kidney diseases such as Polycystic Kidney Disease.
Repository Citation
Praljak, Niksa; Ryan, Shawn D.; and Resnick, Andrew, "Pulsatile Flow Through Idealized Renal Tubules: Fluid-structure Interaction and Dynamic Pathologies" (2020). Mathematics and Statistics Faculty Publications. 339.
https://engagedscholarship.csuohio.edu/scimath_facpub/339
DOI
10.3934/mbe.2020094
Version
Publisher's PDF
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Volume
17
Issue
2
