How Does Knocking Down Specific Genes Cause Dysregulation in Metabolic Pathways?

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Author

Jasline S. Rosario, Cleveland State University

Faculty Advisors

Shamone Gore Panter

Description

Atrial Fibrillation (AF) is an arrhythmia that can cause stroke, heart failure and several other complications. The purpose of this research is to see how knocking down specific genes can cause dysregulation in metabolic pathways in the mitochondria. Oxidative stress on the mitochondria aids in the development of Atrial Fibrillation. A technique called gene knockdown is essential because we can manipulate and reduce genes in favor of what we are trying to find. [We use this technique in C2C12 myotubes because they relate to the way a human’s system works.] This needs to be done because if we can knockdown a certain gene, it could possibly aid in the prevention of atrial fibrillation and reduce the number of cases in patients. *

Publication Date

2019

College

College of Sciences and Health Professions

Department

Biological, Geological and Environmental Sciences

Disciplines

Genetics and Genomics

Recommended Citation

Rosario, Jasline S., "How Does Knocking Down Specific Genes Cause Dysregulation in Metabolic Pathways?" (2019). Undergraduate Research Posters 2019. 9.
https://engagedscholarship.csuohio.edu/u_poster_2019/9

Student Publication

This item is part of the McNair Scholars Program.