Document Type
Article
Publication Date
3-1-2008
Publication Title
The Journal of Steroid Biochemistry and Molecular Biology
Abstract
Recent studies exhibit that 4-hydroxyphenylretinamide (4HPR) decreases aromatase activity in breast and placental cells. The effect of synthetic 4HPR analogs on aromatase and expression was examined in three breast cancer cell lines. Most derivatives did not decrease cellular aromatase activity. Two of the analogs even stimulated aromatase activity at the transcriptional level. Only one derivative significantly decreased aromatase in all three breast cancer cell lines and also suppressed CYP19 gene expression in one of the cell line. Placental microsomal aromatase assay rule out the possibility that this compound directly inhibits the aromatase enzyme. A non-genomic mechanism in suppression of cellular aromatase activity of this compound is proposed.
Recommended Citation
Su, Bin; Mershon, Serena M.; Stonerock, Laura A.; Curley, Robert W. Jr.; and Brueggemeier, Robert W., "4-Hydroxyphenylretinamide (4HPR) Derivatives Regulate Aromatase Activity and Expression in Breast Cancer Cells" (2008). Chemistry Faculty Publications. 371.
https://engagedscholarship.csuohio.edu/scichem_facpub/371
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
10.1016/j.jsbmb.2007.12.005
Version
Postprint
Volume
109
Issue
2017-01-02
Comments
This work was supported by the National Institutes of Health (NIH) Grant R01 CA73698 (to R.W.B.), CA49837 (to R.W.C., Jr.), and The Ohio State University Comprehensive Cancer Center Breast Cancer Research Fund.