Tissue Engineering Approaches for Motor Neuron Pathway Regeneration
Document Type
Article
Publication Date
10-20-2012
Publication Title
Journal of Regenerative Medicine
Abstract
During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.
Repository Citation
Farrell, Kurt and Kothapalli, Chandrasekhar R., "Tissue Engineering Approaches for Motor Neuron Pathway Regeneration" (2012). Chemical & Biomedical Engineering Faculty Publications. 188.
https://engagedscholarship.csuohio.edu/encbe_facpub/188
Original Citation
Farrell K, Kothapalli CR (2012) Tissue Engineering Approaches for Motor Neuron Pathway Regeneration. J Regen Med 1:2. doi:10.4172/2325-9620.1000102
Volume
1
Issue
2
DOI
10.4172/2325-9620.1000102
