Biodegradable HA-PLA 3-D Porous Scaffolds: Effect of Nano-Sized Filler Content on Scaffold Properties

Document Type

Article

Publication Date

11-1-2005

Publication Title

Acta Biomaterialia

Abstract

Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170 °C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25 nm in width and 150 nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50 wt%, the compression modulus of the scaffolds increased from 4.72 ± 1.2 to 9.87 ± 1.8 MPa, while the yield strength from 0.29 ± 0.03 to 0.44 ± 0.01 MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications. © 2005 Actabio Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Volume

1

Issue

6

DOI

10.1016/j.actbio.2005.06.005

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