Document Type
Article
Publication Date
10-31-2024
Publication Title
International Journal of Oral Science
Abstract
The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are considered the gold standard but present critical drawbacks. These shortcomings have driven recent research on craniomaxillofacial bone reconstruction to focus on synthetic grafts with distinct materials and fabrication techniques. Among the various fabrication methods, additive manufacturing (AM) has shown significant clinical potential. AM technologies build three-dimensional (3D) objects with personalized geometry customizable from a computer-aided design. These layer-by-layer 3D biomaterial structures can support bone formation by guiding cell migration/proliferation, osteogenesis, and angiogenesis. Additionally, these structures can be engineered to degrade concomitantly with the new bone tissue formation, making them ideal as synthetic grafts. This review delves into the key advances of bioceramic grafts/scaffolds obtained by 3D printing for personalized craniomaxillofacial bone reconstruction. In this regard, clinically relevant topics such as ceramic-based biomaterials, graft/scaffold characteristics (macro/micro-features), material extrusion-based 3D printing, and the step-by-step workflow to engineer personalized bioceramic grafts are discussed. Importantly, in vitro models are highlighted in conjunction with a thorough examination of the signaling pathways reported when investigating these bioceramics and their effect on cellular response/behavior. Lastly, we summarize the clinical potential and translation opportunities of personalized bioceramics for craniomaxillofacial bone regeneration.
Recommended Citation
de Carvalho, A.B.G., Rahimnejad, M., Oliveira, R.L.M.S. et al. Personalized bioceramic grafts for craniomaxillofacial bone regeneration. Int J Oral Sci 16, 62 (2024). https://doi.org/10.1038/s41368-024-00327-7
DOI
10.1038/s41368-024-00327-7
Version
Publisher's PDF
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Volume
16
Issue
1
Comments
This project was supported by funding from the National Institutes of Health (NIH, National Institute of Dental and Craniofacial Research [R01DE031476 to MCB] and by the São Paulo Research Foundation (FAPESP, projects 2022/03811-9 to ABGC; 2021/ 05259-9 to RLMSO; and 2022/12217-3 to EST