Date of Award

2012

Degree Type

Thesis

Department

Mechanical Engineering

First Advisor

Rashidi, Majid

Subject Headings

MATLAB, Catheter ablation, Arrhythmia, cardiac ablation, MATLAB

Abstract

This thesis presents a mathematical modeling of the cardiac DC ablation procedure. The model treats the procedure as a one dimensional heat transfer phenomenon taking place across the thickness of the myocardium. The model further considers a constant 37 oC for one of the boundary condition of the affected tissue, and the temperature of the other boundary condition is set to be a time dependent square-pulse variations. The parameters defining this time dependent boundary condition is used to perform parametric studies to predict tissue temperature at different depth of the myocardium. The initial condition of the myocardium prior to the ablation procedure is considered to be also constant and at 37 oC. MATLAB was used to solve the parabolic partial differential equation that describes the temperature variations within the myocardium. The duration of off-and-on square-pulse controlled temperature at the inner wall of the myocardium showed to be influential in the depth of intentional lesion within the myocardium. In case of a 1.5-seconds on-time for a 60 oC wall temperature, and a 0.5-second off-time, the time taken to have a lesion depth of 0.26 mm reaching 55 oC was about 6.32 seconds

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