Plasmodium yoelii: Novel Rhoptry Proteins Identified Within the Body of Merozoite Rhoptries in Rodent Plasmodium Malaria
The biogenesis, organization and function of the rhoptries are not well understood. Antisera were prepared to synthetic peptides prepared as multiple antigenic peptides (MAPs) obtained from a Plasmodium yoelii merozoite rhoptry proteome analysis. The antisera were used in immunofluorescence and immunoelectron microscopy of schizont-infected erythrocytes. Twenty-seven novel rhoptry proteins representing proteases, metabolic enzymes, secreted proteins and hypothetical proteins, were identified in the body of the rhoptries by immunoelectron microscopy. The merozoite rhoptries contain a heterogeneous mixture of proteins that may initiate host cell invasion and establish intracellular parasite development. © 2008 Elsevier Inc. All rights reserved.
Sam-Yellowe, Tobili Y.; Banks, Tashara L.; Fujioka, Hisashi; Drazba, Judith A.; and Yadav, Satya P., "Plasmodium yoelii: Novel Rhoptry Proteins Identified Within the Body of Merozoite Rhoptries in Rodent Plasmodium Malaria" (2008). Biological, Geological, and Environmental Faculty Publications. 182.