Bioorganic & Medicinal Chemistry Letters
A series of COX-2 selective inhibitor nimesulide derivatives were synthesized. Their anti-cell proliferation activities were evaluated with a long-term estrogen deprived MCF-7aro (LTEDaro) breast cancer cell line, which is the biological model of aromatase inhibitor resistance for hormone-dependent breast cancer. Compared to nimesulide which inhibited LTEDaro cell proliferation with an IC50 at 170.30 μM, several new compounds showed IC50 close to 1.0 μM.
Su, Bin and Chen, Shiuan, "Lead Optimization of COX-2 Inhibitor Nimesulide Analogs to Overcome Aromatase Inhibitor Resistance in Breast Cancer Cells" (2009). Chemistry Faculty Publications. 400.
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