Document Type
Article
Publication Date
12-1-2009
Publication Title
Bioorganic & Medicinal Chemistry Letters
Abstract
A series of COX-2 selective inhibitor nimesulide derivatives were synthesized. Their anti-cell proliferation activities were evaluated with a long-term estrogen deprived MCF-7aro (LTEDaro) breast cancer cell line, which is the biological model of aromatase inhibitor resistance for hormone-dependent breast cancer. Compared to nimesulide which inhibited LTEDaro cell proliferation with an IC50 at 170.30 μM, several new compounds showed IC50 close to 1.0 μM.
Recommended Citation
Su, Bin and Chen, Shiuan, "Lead Optimization of COX-2 Inhibitor Nimesulide Analogs to Overcome Aromatase Inhibitor Resistance in Breast Cancer Cells" (2009). Chemistry Faculty Publications. 400.
https://engagedscholarship.csuohio.edu/scichem_facpub/400
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
10.1016/j.bmcl.2009.09.109
Version
Postprint
Volume
19
Issue
23
Comments
This work was supported by grants from the National Institutes of HealthCA44735 (S.C.), ES08528 (S.C.).