2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its activator, 5'-phosphorylated, 2'-5' linked oligoadenylates (2-5A), RNase L degrades single-stranded viral and cellular RNAs and thus plays an important role in the antiviral and antiproliferative functions of IFNs. In recent years, evidence has revealed that RNase L displays a broad range of biological roles which are summarized in this review.
Liang, Shu Ling; Quirk, David; and Zhou, Aimin, "RNase L: Its Biological Roles and Regulation" (2006). Chemistry Faculty Publications. 407.
This is the accepted version of the following article: Liang, S.; Quirk, D.; Zhou, A. RNase L: Its biological roles and regulation. IUBMB Life 2006, 58, 508-514., which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1080/15216540600838232/abstract