Natural Products as Aromatase Inhibitors
Document Type
Article
Publication Date
2008
Publication Title
Anti-Cancer Agents in Medicinal Chemistry
Abstract
With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always available through current synthetic chemistry techniques. Natural products that have been used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may also afford AIs with reduced side effects. A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein.
Recommended Citation
Balunas, Marcy J.; Su, Bin; Brueggemeier, Robert W.; and Kinghorn, A. Douglas, "Natural Products as Aromatase Inhibitors" (2008). Chemistry Faculty Publications. 437.
https://engagedscholarship.csuohio.edu/scichem_facpub/437
DOI
10.2174/187152008785133092
Volume
8
Issue
6
