ORCID ID

http://orcid.org/0000-0002-5140-1504

Document Type

Article

Publication Date

2017

Publication Title

ECS Transactions

Abstract

Peroxynitrite (PON) is a highly reactive oxygen-nitrogen species that facilitates both oxidation and nitration reactions. Early reports have revealed the deleterious effects of PON on DNA, proteins, and lipids. Recent studies have suggested that melanin can act as an antioxidative therapy to scavenge the reactive oxygen-nitrogen species (RO-NS) including PON. Melanin is a natural pigment that has many physiological functions involving the neutralization of highly oxidative species. In this project, the interaction between PON and synthetic melanin has been studied. In addition, the electrochemical characteristics of the polymerized 5,6-dihydroxy indole (DHI) as a model of synthetic melanin were examined using cyclic voltammetry and electrochemical quartz crystal microbalance (EQCM). The ultraviolet-visible (UV-Vis) spectroscopy showed a significant difference in the absorbance of PON alone and in the presence of melanin films. Finally, we report on the possibility of using the DHI-melanin film as a platform for the quantitative detection of PON in solutions.

DOI

10.1149/08010.1447ecst

Version

Postprint

Volume

80

Issue

10

Download

Included in

Chemistry Commons

Share

COinS