Document Type
Article
Publication Date
11-1-2008
Publication Title
Journal of Infectious Diseases
Abstract
We examined the role that immunoglobulin GM and KM allotypes—genetic markers of γ and κ chains, respectively—play in the outcome of hepatitis C virus (HCV) infection in white Americans. A total of 119 persons who had cleared HCV and 111 with persistent HCV infection were genotyped for the presence of several GM and KM determinants. Persistent HCV infection was more than three times as likely (odds ratio, 3.50; P = .01) in subjects who were carriers of the GM3 allele than in those who were noncarriers. These results show that particular GM alleles may be important determinants of the outcome of HCV infection.
Repository Citation
Pandey, Janardan P.; Namboodiri, Aryan M.; Luo, Yuqun; Wu, Yuping; Elston, Robert C.; Thomas, David L.; Rosen, Hugo R.; and Goedert, James J., "Genetic Markers of IgG Influence The Outcome of Infection with Hepatitis C Virus" (2008). Mathematics and Statistics Faculty Publications. 194.
https://engagedscholarship.csuohio.edu/scimath_facpub/194
DOI
10.1086/592282
Version
Postprint
Publisher's Statement
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Journal of Infectious Diseases following peer review. The version of record Pandey, Janardan P. et al. "Genetic Markers of Igg Influence the Outcome of Infection with Hepatitis C Virus." The Journal of Infectious Diseases, vol. 198, no. 9, 2008, pp. 1334-1336, doi:10.1086/592282. is available online at: https://academic.oup.com/jid/article-lookup/doi/10.1086/592282
Volume
198
Issue
9
Comments
National Institutes of Health (grants DK070877 to J.P.P., DA13224 to D.L.T., and HG003054 to Y.L.).