Document Type

Article

Publication Date

7-1-2013

Publication Title

Arteriosclerosis, Thrombosis, and Vascular Biology

Abstract

Objective—Diminished cholesterol efflux activity of apolipoprotein B (apoB)–depleted serum is associated with prevalent coronary artery disease, but its prognostic value for incident cardiovascular events is unclear. We investigated the relationship of cholesterol efflux activity with both prevalent coronary artery disease and incident development of major adverse cardiovascular events (death, myocardial infarction, or stroke). Approach and Results—Cholesterol efflux activity from free cholesterol–enriched macrophages was measured in 2 case–control cohorts: (1) an angiographic cohort (n=1150) comprising stable subjects undergoing elective diagnostic coronary angiography and (2) an outpatient cohort (n=577). Analysis of media from cholesterol efflux assays revealed that the high-density lipoprotein fraction (1.063

Comments

This research was supported by National Institutes of Health grant P01HL098055 and by the Fondation LeDucq. GeneBank has been supported by National Institutes of Health grants P01HL076491, R01HL103866, R01HL103931, and P20HL113452 and the Cleveland Clinic Clinical Research Unit of the Case Western Reserve University The Clinical and Translational Science Collaborative (UL1TR 000439-06).

DOI

10.1161/ATVBAHA.113.301373

Version

Postprint

Volume

33

Issue

7

Included in

Mathematics Commons

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