Paradoxical Association of Enhanced Cholesterol Efflux With Increased Incident Cardiovascular Risks
Arteriosclerosis, Thrombosis, and Vascular Biology
Objective—Diminished cholesterol efflux activity of apolipoprotein B (apoB)–depleted serum is associated with prevalent coronary artery disease, but its prognostic value for incident cardiovascular events is unclear. We investigated the relationship of cholesterol efflux activity with both prevalent coronary artery disease and incident development of major adverse cardiovascular events (death, myocardial infarction, or stroke). Approach and Results—Cholesterol efflux activity from free cholesterol–enriched macrophages was measured in 2 case–control cohorts: (1) an angiographic cohort (n=1150) comprising stable subjects undergoing elective diagnostic coronary angiography and (2) an outpatient cohort (n=577). Analysis of media from cholesterol efflux assays revealed that the high-density lipoprotein fraction (1.063
Li, Xin Min; Tang, Wai Hong Wilson; Mosior, Marian K.; Huang, Ying; Wu, Yuping; Matter, William; Gao, Vivian; Schmitt, David; DiDonato, Joseph A.; Fisher, Edward A.; Smith, Jonathan D.; and Hazen, Stanley L., "Paradoxical Association of Enhanced Cholesterol Efflux With Increased Incident Cardiovascular Risks" (2013). Mathematics Faculty Publications. 214.
This research was supported by National Institutes of Health grant P01HL098055 and by the Fondation LeDucq. GeneBank has been supported by National Institutes of Health grants P01HL076491, R01HL103866, R01HL103931, and P20HL113452 and the Cleveland Clinic Clinical Research Unit of the Case Western Reserve University The Clinical and Translational Science Collaborative (UL1TR 000439-06).