Document Type
Article
Publication Date
5-29-2015
Publication Title
Photonics
Abstract
Cilia are slender flexible structures extending from the cell body; genetically similar to flagella. Although their existence has been long known, the mechanical and functional properties of non-motile (“primary”) cilia are largely unknown. Optical traps are a non-contact method of applying a localized force to microscopic objects and an ideal tool for the study of ciliary mechanics. We present a method to measure the mechanical properties of a cilium using an analytic model of a flexible, anchored cylinder held within an optical trap. The force density is found using the discrete-dipole approximation. Utilizing Euler-Bernoulli beam theory, we then integrate this force density and numerically obtain the equilibrium deformation of the cilium in response to an optical trap. The presented results demonstrate that optical trapping can provide a great deal of information and insight about the properties and functions of the primary cilium.
Repository Citation
Lofgren, Ian and Resnick, Andrew, "A Model for the Force Exerted on A Primary Cilium by An Optical Trap and The Resulting Deformation" (2015). Physics Faculty Publications. 247.
https://engagedscholarship.csuohio.edu/sciphysics_facpub/247
DOI
10.3390/photonics2020604
Version
Publisher's PDF
Publisher's Statement
Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Volume
2
Issue
2
Comments
The research was supported by the NIH DK092716 award.