Structure-Function of U11 snRNA in the Minor Splicing Pathway

Authors

Mark P. Biro, Cleveland State UniversityFollow
Jagjit Singh, Cleveland State UniversityFollow

Files

Description

In human, the majority of protein coding genes are interrupted by dispensable intervening sequences (introns). These introns are removed by nuclear precursor (pre) mRNA splicing process to produce a mature mRNA needed for productive protein production in the cell. We are studying the splicing of minor class or U12-type introns which are spliced by U11, U12, U4atac, U5 and U6atac snRNAs. U11 snRNA binds to the 5’ end or splice site of the intron by RNA-RNA base-pairing to initiate the splicing process. Our results show the functionality of the genetic mutation suppressor assay in establishing the role of U11 snRNA in nuclear pre-mRNA splicing.

Publication Date

9-6-2012

Disciplines

Genetics and Genomics | Genomics | Life Sciences

Comments

Student Researchers: Mark Biro; Jagjit Singh

Faculty Advisor: Girish C Shukla, Ph.D.

Recommended Citation

Biro, Mark P. and Singh, Jagjit, "Structure-Function of U11 snRNA in the Minor Splicing Pathway" (2012). Undergraduate Research Posters 2012. 41.
https://engagedscholarship.csuohio.edu/u_poster_2012/41