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Layer-by-Layer Printing of Alginate for Cancer Cell Migration Assays
Yana Sichar, Alexander Roth, Emily Serbinowski, and Kyeong Nam Yu
Rapid assessment of the invasion potential of various cancers in three-dimensional (3D) cell culture via layer-by-layer printing of cells encapsulated in hydrogels has been studied. Microarray bioprinting technology on microwell chips has been explored to create 3D cancer-like tissue structures and study cancer cell migration. Alginate, a negatively charged biopolymer, forms hydrogels via ionic crosslinking. Oxy-methacrylated alginate (OMA) is polymerized via near-ultraviolet light in the presence of photoinitiators. Our goal is to demonstrate rapid creation of cancer tissuelike structures via microarray 3D-bioprinting and develop a high-throughput, 3D cancer cell migration ... Read More
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Design and Fabrication of a Microfluidic Device using a 3D Printer
Aaron Smith
The goal of this work was to design and implement a microfluidic mixer-based chemical reactor using a 3-D printer. Microfluidic devices are very useful for processes that use expensive reactants or require a high level of control, and we hypothesize that the ability to develop a prototype using a 3-D printer would lower their costs and help overcome some of the limitations of soft-lithography based devices. One-level and two-level designs were made using SolidWorks® software, and various stages of the model were printed on Objet® and FDM® printers. The Objet ... Read More
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How does educational opportunities influence decisions for Nigerian girls and the society?
Shalonda Swanson
This paper raises questions about educational opportunities for Nigerian girls to understand if traditional Islamic or Western education influence the girls on various factors; including, their religious connections, optimism for their future, and the value in Islamic education compared to Western education. To discuss the current status of the country the paper discusses the historical underlying factors that influenced Nigeria's policies for educational opportunities for girls. Nigeria has struggled with gender disparities that disproportionately provided educational opportunities for boys at an increased rate compared to girls. This research reports the ... Read More
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How Dry is the Lower Atmosphere: Finding Relations Between Various Moments in the Atmospheric Boundary Layer
Vladimir Sworski
The Atmospheric Boundary Layer (ABL), consisting of the bottom few kilometers of the troposphere, is a highly turbulent region with strong mixing of moisture and winds. This region's activity is driven by thermals, which rise to the top of the boundary layer and thicken it through entrainment of warm air from above. To better predict the behavior of the ABL, a good understanding of the distribution of heat, moisture and momentum is important. In this study, we use a high resolution computer model (LES) to determine those distributions. We were ... Read More
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Designing Genes that Encode Proteins for Biomedical Applications
Isaiah Traben
DNA is a crucial component of all known life. It encodes in genes the structure of the proteins necessary to perform many of the functions in a cell. Proteins are biological polymers consisting of a chain of amino acids. The specific sequence of the amino acids determines the structure and therefore function of the protein. The sequence of the amino acids of a protein is coded in DNA via triplets of the nucleotide bases known as codons, which each can represent only one amino acid. However, an amino acid can ... Read More
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Light Scattering Characterization of Elastin-Like Polypeptide Trimer Micelles
Ilona Tsuper, Daniel Terrano, and Adam Maraschky
Elastin-Like Polypeptides (ELP) can be used to form thermo-reversible vehicles for drug delivery systems. The ELP nanoparticles are composed of three-armed star polypeptides. Each of the three arms extending from the negatively charged foldon domain includes 20 repeats of the (GVGVP) amino acid sequence. The ELP polymer chains are soluble at room temperature and become insoluble at the transition temperature (close to 50 oC), forming micelles. The size and shape of the micelle is dependent on the temperature and the pH of solution, along with the concentration of the Phosphate ... Read More
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Light Scattering Study of Mixed Micelles Made from Elastin-Like Polypeptide Linear Chains and Trimers
Ilona Tsuper, Daniel Terrano, and Adam Maraschky
Temperature sensitive nanoparticles (E20F) were generated from a construct of three chains of Elastin- Like Polypeptides (ELP) linked to a negatively charged foldon domain. This ELP system was mixed at different ratios with a single linear chain of ELP (H40L) which was deprived of the foldon domain. The mixed system is soluble at room temperature and at a transition temperature will form swollen micelles with the hydrophobic linear chains hidden inside. This system was studied using Depolarized Dynamic Light Scattering (DDLS) and Static Light Scattering (SLS) to model the size, ... Read More
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Bioinformatic Analysis of the Sodium Hydrogen Exchanger Protein in Plasmodium yoelii
Jamira Virk and Raghavendra Yadavalli
Since its discovery over 100 years ago, malaria has been the most important parasitic disease in the world. Malaria affects about 300 to 500 million people every year; killing 5 million people every year. The most virulent causative agent in humans is Plasmodium falciparum; it is an important member of the phylum Apicomplexa, which also includes Toxoplasma gondii. These organisms contain specialized, unique structures, including rhoptry organelles. In Plasmodium and Toxoplasma gondii, they assist invasion into the host cell. Analyses have been performed on proteins located in rhoptries in Toxoplasma ... Read More
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GPU Assisted High Performance RSA Encryption
Zhe Zhao and Alec McGrady
GPU has become highly popular due to its parallel computing ability. It accelerates operations in large scale. Many applications associate with intensive computations. RSA cryptosystem is one of them that can benefit from its utility. The purpose of this research is to implement RSA encryption and decryption by utilizing GPU to enhance the performance of the process. Since RSA public key and private key operations actually consist of large integer multiplications in a finite field, this research explores the efficient algorithms and implementations of the high performance GPU large integer ... Read More
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