SFRP-4, TLRs, And EVs Signaling Play Critical Roles in Type Two Diabetes

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Author

Anthony K. Graley, Cleveland State University

Faculty Advisors

Ángel L. Reyes-Rodríguez

Description

Type two diabetes mellitus is a metabolic disorder characterized by insulin resistance and insulin deficiency that resulted from the expression and suppression of polygenic-based signal pathways while under hyperglycemic conditions. These pathways often result in pancreatic β-cell dysfunction, β -cell apoptosis, and poor metabolic control. Available glycemic control treatments are often inefficient and therefore, there is a need for additional therapeutic treatments and targets. To better understand the genetic complexities of type two diabetes, a literature review was conducted from scholarly articles, and a framework was built to explain the pathogenic pathways involved in type two diabetes. Specifically, Toll-like receptors (TLRs), Secreted Frizzled Related Protein Four (SFRP-4), and extracellular vesicles (EVs) were examined, and their interconnective inflammatory mechanisms explored. The study of how these pathways create feedback loops among each other that have the potential to result in the identification of novel therapeutic targets that better regulate this complex disorder.

Publication Date

2022

College

College of Sciences and Health Professions

Recommended Citation

Graley, Anthony K., "SFRP-4, TLRs, And EVs Signaling Play Critical Roles in Type Two Diabetes" (2022). Undergraduate Research Posters 2022. 12.
https://engagedscholarship.csuohio.edu/u_poster_2022/12

Student Publication

This item is part of the McNair Scholars Program.