Document Type

Article

Publication Date

2013

Publication Title

Molecules

Abstract

Using pregnenolone and 7-deoxycholic acid as starting materials, some 17-acetamidoandrostane and N,N-dimethyl-7-deoxycholic amide derivatives were synthesized. The cytotoxicity of the synthesized compounds was tested in vitro against two tumor cell lines: SGC 7901 (human gastric carcinoma) and Bel 7404 (human liver carcinoma). The result showed that the blockage of the interaction of the amide group with outside groups might cause a decrease of the cytotoxicity, and an O-benzyloximino group at the 3-position of N,N-dimethyl-7-deoxycholic amide could enhance the cytotoxic activity of the compound. The information obtained from the studies provides the structure-activity relationship for these compounds and may be useful for the design of novel chemotherapeutic drugs.

Comments

The authors acknowledge the financial support of the National Science Foundation of Guangxi Province (No. 2010GXNSFA013019, No. 2010GXNSFD13052) and Natural Science Fund of Education Department of Guangxi Province (No. 201202ZD059).

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

DOI

10.3390/molecules18077436

Version

Publisher's PDF

Volume

18

Issue

7

Included in

Chemistry Commons

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