Document Type
Article
Publication Date
2013
Publication Title
Molecules
Abstract
Using pregnenolone and 7-deoxycholic acid as starting materials, some 17-acetamidoandrostane and N,N-dimethyl-7-deoxycholic amide derivatives were synthesized. The cytotoxicity of the synthesized compounds was tested in vitro against two tumor cell lines: SGC 7901 (human gastric carcinoma) and Bel 7404 (human liver carcinoma). The result showed that the blockage of the interaction of the amide group with outside groups might cause a decrease of the cytotoxicity, and an O-benzyloximino group at the 3-position of N,N-dimethyl-7-deoxycholic amide could enhance the cytotoxic activity of the compound. The information obtained from the studies provides the structure-activity relationship for these compounds and may be useful for the design of novel chemotherapeutic drugs.
Recommended Citation
Huang, Yanmin; Cui, Jianguo; Jia, Linyi; Gan, Chunfang; Song, Huacan; Zeng, Chun; and Zhou, Aimin, "Synthesis and Evaluation of Some 17-Acetamidoandrostane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity Studies" (2013). Chemistry Faculty Publications. 415.
https://engagedscholarship.csuohio.edu/scichem_facpub/415
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
DOI
10.3390/molecules18077436
Version
Publisher's PDF
Volume
18
Issue
7
Comments
The authors acknowledge the financial support of the National Science Foundation of Guangxi Province (No. 2010GXNSFA013019, No. 2010GXNSFD13052) and Natural Science Fund of Education Department of Guangxi Province (No. 201202ZD059).