Sequence Analysis of the Rhop-3 Gene of Plasmodium yoelii

Document Type

Article

Publication Date

1-1-2000

Publication Title

Journal of Eukaryotic Microbiology

Disciplines

Biology

Abstract

The 110 kDa/Rhop-3 rhoptry protein of Plasmodium falciparum is non-covalently associated with two other proteins, the 140 kDa Rhop-1 and the 130 kDa Rhop-2. cDNAs encoding Rhop-3 from Plasmodium yoelii were isolated using rhoptry-specific antisera from Plasmodium falciparum, P. yoelii, and Plasmodium chabaudi. The cDNAs encoded peptides with partial homology to the C-terminal region (residues 541-861) of P. falciparum Rhop-3. Core regions of homology to the P. falciparum gene will be useful in determining the biological role of Rhop-3 and its potential as a vaccine candidate for malaria.

DOI

10.1111/j.1550-7408.2000.tb00053.x

Volume

47

Issue

3

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