Document Type
Article
Publication Date
9-15-2011
Publication Title
Bioorganic & Medicinal Chemistry Letters
Abstract
JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive breast cancer cells. However, the specific molecular targets of JCC76 still remain unclear, which significantly withdraw the further drug development of JCC76. To identify the molecular targets of JCC76, a six carbon linker and biotin conjugated JCC76 probe was designed and synthesized. The anti-proliferation activity of the probe and its analogs was evaluated.
Recommended Citation
Zhong, Bo; Lama, Rati; Smith, Kerri M.; Xu, Yan; and Su, Bin, "Design and Synthesis of A Biotinylated Probe of COX-2 Inhibitor Nimesulide Analog JCC76" (2011). Chemistry Faculty Publications. 174.
https://engagedscholarship.csuohio.edu/scichem_facpub/174
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
DOI
10.1016/j.bmcl.2011.07.025
Version
Postprint
Volume
21
Issue
18
