Screw-Cap Clamp Loader Proteins that Thread
Document Type
Article
Publication Date
2004
Publication Title
Nature Structural and Molecular Bology
Abstract
Structures of the clamp loader–clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication.
Recommended Citation
Zhuang, Zhihao; Spiering, Michelle M.; Berdis, Anthony J.; Trakselis, Michael A.; and Benkovic, Stephen J., "Screw-Cap Clamp Loader Proteins that Thread" (2004). Chemistry Faculty Publications. 275.
https://engagedscholarship.csuohio.edu/scichem_facpub/275
DOI
10.1038/nsmb0704-580
Volume
11
