Document Type
Article
Publication Date
2013
Publication Title
Analyst
Abstract
Conducting interfaces modified with reduced graphene oxide (rGO) have shown improved electrochemical response for different analytes. The efficient formation of functionalized rGO based materials is thus of current interest for the development of sensitive and selective biosensors. Herein, we report a simple and environmentally friendly method for the formation of a hemin-functionalized rGO hybrid nanomaterial that exhibits remarkable sensitivity to peroxynitrite (ONOO−) in solution. The hemin-functionalized rGO hybrid nanomaterial was formed by mixing an aqueous solution of graphene oxide (GO) with hemin and sonicating the suspension for 5 h at room temperature. In addition to playing a key role in biochemical and electrocatalytic reactions, hemin has been proven to be a good reducing agent for GO. The sensitivity of the peroxynitrite sensor is ≈7.5 ± 1.5 nA mM−1 with a detection limit of 5 ± 1.5 nM.
Recommended Citation
Oprea, Raluca; Peteu, Serban F.; Subramanian, Palaniappan; Qi, Wang; Pichonat, Emmanualle; Happy, Henri; Bayachou, Mekki; Boukherroub, Rabah; and Szunerits, Sabine, "Peroxynitrite Activity of Hemin-Functionalized Reduced Graphene Oxide" (2013). Chemistry Faculty Publications. 322.
https://engagedscholarship.csuohio.edu/scichem_facpub/322
DOI
10.1039/c3an00678f
Version
Postprint
Volume
138
Issue
15
Comments
M.B. acknowledges funding by The National Science Foundation (to MB, Grant CHE-0848820), by an FRD grant from Ohio Board of Regents, and by funds from Cleveland State University.