Document Type
Article
Publication Date
7-1-2012
Publication Title
Steroids
Abstract
Here we report that 6-hydroximino-4-aza-A-homo-cholest-3-one and 6-hydroxyl-4-aza-A-homo-cholest-3-one, new steroidal lactams were synthesized recently, displayed antiproliferative activity against some cancer cells through inducing cancer cell apoptosis by activation of the intrinsic pathway. The apoptotic function of the compounds was demonstrated by release of cytochrome C, activation of caspase 3 and annexin V labeling. Furthermore, the compound was able to inhibit tumor growth in an athymic mouse model.
Recommended Citation
Huang, Yanmin; Cui, Jianguo; Zheng, Qiaoxia; Zeng, Chun; Chen, Quan; and Zhou, Aimin, "6-Hydroximino-4-Aza-A-Homo-Cholest-3-One and Related Analogue as A Potent Inducer of Apoptosis in Cancer Cells" (2012). Chemistry Faculty Publications. 372.
https://engagedscholarship.csuohio.edu/scichem_facpub/372
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
10.1016/j.steroids.2012.04.016
Version
Postprint
Volume
77
Issue
2017-08-09
Comments
The authors acknowledge the financial support of the Natural Science Foundation of Guangxi Province, P.R. of China. (No: 2010GXNSFD013019).