Document Type
Article
Publication Date
11-1-2009
Publication Title
Steroids
Abstract
Hydroximinosteroids isolated from marine sponges display a variety of biological functions including cytotoxicity and anti-virus. In this study, we synthesized a series of hydroximinosteroid derivatives with a different functional group on the ring A or B and various side chains at position 17, and analyzed the cytotoxicity of these compounds against sk-Hep-1, H-292, PC-3 and Hey-1B cancer cells. Our results revealed that although a cholesterol-type side chain at position 17 is required for the biological activity of the compounds as we previously confirmed, elimination of the 4,5-double bond augmented the cytotoxic activity for the steroidal oximes. In addition, the presence of a hydroxy on 3- or 6-position of the steroidal nucleus resulted in a remarkable increase of cytotoxic activity. Our findings present more evidence showing the relationship between the chemical structure and biological function.
Recommended Citation
Cui, Jianguo; Fan, Lei; Huang, Yanmin; Xin, Yi; and Zhou, Aimin, "Synthesis and Evaluation of Some Steroidal Oximes as Cytotoxic Agents: Structure/Activity Studies (II)" (2009). Chemistry Faculty Publications. 418.
https://engagedscholarship.csuohio.edu/scichem_facpub/418
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
10.1016/j.steroids.2009.07.009
Version
Postprint
Volume
74
Issue
12
Comments
The authors acknowledge the financial support of the National Natural Science Foundation of China (no.: 20562001), the Natural Science Foundation of Guangxi Province (no.: 0832106) and the Foundation of Guangxi Education Bureau (200707M5172).