Document Type
Article
Publication Date
11-19-2002
Publication Title
Carbohydrate Research
Abstract
A disulfated tetrasaccharide fragment with a spacer arm of human hepatocellular carcinoma carbohydrate antigen SB1a, namely, 2-aminoethyl 3-O-sulfo-β-d-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-β-d-galactopyranosyl-(1→4)-3-O-sulfo-β-d-galactopyranosyl-(1→4)-β-d-glucopyranoside was synthesized via a [2+1+1] block building mode. In the last coupling step toward the trisaccharide acceptor 8, benzoyl protected galactosyl bromide donor 14 was found to be much more reactive than the acetyl-protected donors. A disulfated tetrasaccharide fragment with a spacer arm of human hepatocellular carcinoma carbohydrate antigen SB1a was synthesized via a [2+1+1] block building mode.
Recommended Citation
Li, Qin; Li, Hui; Li, Qing; Lou, Qing Hua; Su, Bin; Cai, Meng Shen; and Li, Zhong Jun, "Synthesis of A Spacer-Armed Disulfated Tetrasaccharide of SB1a, A Carbohydrate Hapten Associated with Human Hepatocellular Carcinoma" (2002). Chemistry Faculty Publications. 420.
https://engagedscholarship.csuohio.edu/scichem_facpub/420
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
10.1016/S0008-6215(02)00291-4
Version
Postprint
Volume
337
Issue
21-23
