A disulfated tetrasaccharide fragment with a spacer arm of human hepatocellular carcinoma carbohydrate antigen SB1a, namely, 2-aminoethyl 3-O-sulfo-β-d-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-β-d-galactopyranosyl-(1→4)-3-O-sulfo-β-d-galactopyranosyl-(1→4)-β-d-glucopyranoside was synthesized via a [2+1+1] block building mode. In the last coupling step toward the trisaccharide acceptor 8, benzoyl protected galactosyl bromide donor 14 was found to be much more reactive than the acetyl-protected donors. A disulfated tetrasaccharide fragment with a spacer arm of human hepatocellular carcinoma carbohydrate antigen SB1a was synthesized via a [2+1+1] block building mode.
Li, Qin; Li, Hui; Li, Qing; Lou, Qing Hua; Su, Bin; Cai, Meng Shen; and Li, Zhong Jun, "Synthesis of A Spacer-Armed Disulfated Tetrasaccharide of SB1a, A Carbohydrate Hapten Associated with Human Hepatocellular Carcinoma" (2002). Chemistry Faculty Publications. 420.
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