Separation of 4 Galactosyl -2-Azido -2-Deoxy Mannose 1-Nitrate and Corresponding Glucose Type Isomer by Glycosylation

Document Type

Article

Publication Date

2001

Publication Title

Beijing Daxue Xuebao

Abstract

To separate two oligosaccharide isomers which have very similar polarity and to try a new method of glycosylation. Methods: Some mannose type derivatives can be prepared selectively by glycosylation of a mixture of mannose type 1 nitrate and corresponding glucose type isomer, which is obtained from azidonitration of lactal. In the mean time, glucose type 1 nitrate can be separated. Results: Eight mannose type α glycosides and esters were synthesized stereoselectively in high yields and pure glucose type 1 nitrate was recovered. Conclusion: Two oligosaccharide isomers which had the same polarity could be separated according to their difference of olycosylation reactivity; It may offer a new path to sythesize 2 amino 2 deoxy oligosaccharides by using glycosyl 1 nitration as donor.

Volume

33

Issue

3

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