Separation of 4 Galactosyl -2-Azido -2-Deoxy Mannose 1-Nitrate and Corresponding Glucose Type Isomer by Glycosylation
Beijing Daxue Xuebao
To separate two oligosaccharide isomers which have very similar polarity and to try a new method of glycosylation. Methods: Some mannose type derivatives can be prepared selectively by glycosylation of a mixture of mannose type 1 nitrate and corresponding glucose type isomer, which is obtained from azidonitration of lactal. In the mean time, glucose type 1 nitrate can be separated. Results: Eight mannose type α glycosides and esters were synthesized stereoselectively in high yields and pure glucose type 1 nitrate was recovered. Conclusion: Two oligosaccharide isomers which had the same polarity could be separated according to their difference of olycosylation reactivity; It may offer a new path to sythesize 2 amino 2 deoxy oligosaccharides by using glycosyl 1 nitration as donor.
Li, Qing; Li, Hui; Su, Bin; Meng, Xiang Bao; Cai, Meng Shen; and Li, Zhong Jun, "Separation of 4 Galactosyl -2-Azido -2-Deoxy Mannose 1-Nitrate and Corresponding Glucose Type Isomer by Glycosylation" (2001). Chemistry Faculty Publications. 443.