Synthesis and Antitumour Activities of A Novel Class of Dehydroabietylamine Derivatives
Document Type
Article
Publication Date
2012
Publication Title
Natural Product Research
Abstract
Structural modification is still a popular and important route in the forest chemical field for finding novel tricyclic diterpenes with more potential bioactivities and broad bioactive spectra. In this study, a series of dehydroabietylamine derivatives containing tricyclic diterpene structures were synthesised through oxidation in the 7th position of ring B and nitrification in the 12th position of ring C using dehydroabietylamine as the starting material. Structures of the synthesised compounds were confirmed by IR, 1H-NMR, 13C-NMR, MS and HRMS. The cytotoxicities of these compounds against PC-3 (human prostate carcinoma cell line) and Hey-1B (human ovarian carcinoma cell line) cells by the MTT assay were investigated. The results showed that the presence of a nitro group at 12th position and a carbonyl group at 7th position resulted in an increase of cytotoxic activity. Our findings present more evidence, showing the relationship between the chemical structure and biological function.
Recommended Citation
Chen, Yong; Lin, Zhong Xiang; and Zhou, Aimin, "Synthesis and Antitumour Activities of A Novel Class of Dehydroabietylamine Derivatives" (2012). Chemistry Faculty Publications. 450.
https://engagedscholarship.csuohio.edu/scichem_facpub/450
DOI
10.1080/14786419.2011.648191
Volume
26
Issue
23
