Synthesis of RGD-aPEG-Lactoside, A Potential Anti-Metastasis Glycoconjugate

Document Type

Article

Publication Date

2002

Publication Title

Journal of Chinese Pharmaceutical Sciences

Abstract

The adhesive interaction between tumor cells and host cells or the extra cellular matrix plays a crucial role in metastasis. Due to the anti-metastasis effects of RGD (Arginyl-Glycyl-Aspartic acid) conjugated with PEG, hybrids of PEG armed RGD and oligosaccharides would have potential regulating effects during the metastasis process. In order to investigate this effect, GD-aPEG-Lactosid, RGD-aPEG-Lactoside glycopeptides armed by PEG were designed and successfully prepared by DCC-HOBt coupling method from aPEG-Lactoside, Boc-Gly-Asp(OBn)-OH.

Volume

11

Issue

3

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