Synthesis of RGD-aPEG-Lactoside, A Potential Anti-Metastasis Glycoconjugate
Journal of Chinese Pharmaceutical Sciences
The adhesive interaction between tumor cells and host cells or the extra cellular matrix plays a crucial role in metastasis. Due to the anti-metastasis effects of RGD (Arginyl-Glycyl-Aspartic acid) conjugated with PEG, hybrids of PEG armed RGD and oligosaccharides would have potential regulating effects during the metastasis process. In order to investigate this effect, GD-aPEG-Lactosid, RGD-aPEG-Lactoside glycopeptides armed by PEG were designed and successfully prepared by DCC-HOBt coupling method from aPEG-Lactoside, Boc-Gly-Asp(OBn)-OH.
Niu, Limin; Li, Qing; Su, Bin; Li, Hui; Cai, Meng Shen; and Li, Zhong Jun, "Synthesis of RGD-aPEG-Lactoside, A Potential Anti-Metastasis Glycoconjugate" (2002). Chemistry Faculty Publications. 455.