Xanthones From The Botanical Dietary Supplement Mangosteen (Garcinia mangostana) with Aromatase Inhibitory Activity
Document Type
Article
Publication Date
7-1-2008
Publication Title
Journal of Natural Products
Abstract
Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay. Of these compounds, garcinone D (3), garcinone E (5), α-mangostin (8), and γ-mangostin (9) exhibited dose-dependent inhibitory activity. In a follow-up cell-based assay using SK-BR-3 breast cancer cells that express high levels of aromatase, the most potent of these four xanthones was γ-mangostin (9). Because xanthones may be consumed in substantial amounts from commercially available mangosteen products, the consequences of frequent intake of mangosteen botanical dietary supplements require further investigation to determine their possible role in breast cancer chemoprevention.
Recommended Citation
Balunas, Marcy J.; Su, Bin; Brueggemeier, Robert W.; and Kinghorn, A. Douglas, "Xanthones From The Botanical Dietary Supplement Mangosteen (Garcinia mangostana) with Aromatase Inhibitory Activity" (2008). Chemistry Faculty Publications. 459.
https://engagedscholarship.csuohio.edu/scichem_facpub/459
DOI
10.1021/np8000255
Volume
71
Issue
7
Comments
We are grateful for financial support through a University Fellowship and a Dean’s Scholar Award from the Graduate College of the University of Illinois at Chicago, awarded to M.J.B. Other support was provided by NIH grant R01 CA73698 (P.I., R.W.B.), The Ohio State University Comprehensive Cancer Center (OSUCCC) Breast Cancer Research Fund (to R.W.B.), and the OSUCCC Molecular Carcinogenesis and Chemoprevention Program (to A.D.K.).