Document Type
Article
Publication Date
9-10-2019
Publication Title
ACS Omega
Abstract
The cobalt(II) complex salts [Co(bpy)(az)2](PF6)2 and [Co(az)4](PF6), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.
Recommended Citation
Alghamdi, Norah J.; Balaraman, Lakshmi; Emhoff, Kylin A.; Salem, Ahmed M.H.; Wei, Ruhan; Zhou, Aimin; and Boyd, W. Christropher, "Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells" (2019). Chemistry Faculty Publications. 516.
https://engagedscholarship.csuohio.edu/scichem_facpub/516
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
DOI
10.1021/acsomega.9b01684
Version
Publisher's PDF
Volume
4
Issue
11
Comments
K.A.E. was supported by a Graduate Student Research Award from Cleveland State University. A.Z. was supported by a Gene Regulation in Health and Disease (GRHD) Award from Cleveland State University.