Chemically-Selective Surface Glyco-Functionalization of Liposomes Through Staudinger Ligation

Authors

Hailong Zhang, Cleveland State University
Yong Ma, Cleveland State University
Xue-Long Sun, Cleveland State UniversityFollow

Document Type

Article

Publication Date

5-22-2009

Publication Title

Chemical Communications

Abstract

An efficient and chemoselective liposome surface glyco-functionalization method has been developed based on Staudinger ligation, in which the carbohydrate derivative carrying an azide spacer is conjugated onto the surface of preformed liposomes bearing a terminal triphosphine in PBS buffer (pH 7.4) at room temperature.

Comments

The authors acknowledge financial support under grants from American Health Assistance Foundation (AHAF-H2007027) and the Startup Fund from Cleveland State University.

Recommended Citation

Zhang, H.; Ma, Y.; Sun, X. Chemically-selective surface glyco-functionalization of liposomes through Staudinger ligation. Chemical Communications 2009, 2009, 3032-3034.

DOI

10.1039/b822420j

Issue

21