Effects of the Dysregulation of PANCR Regarding the PITX2 Gene in the Eye

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Author

Mohamed Najjar, Cleveland State University

Faculty Advisors

Shamone Gore Panter

Description

The PITX2 adjacent noncoding RNA (PANCR) is an intergenic long noncoding RNA adjacent to the PITX2 gene. The PITX2 gene functions as a regulator for bilateral symmetry during development. PANCR is only expressed in the left atrium of the heart and in the eye in humans. PANCR has been studied with its effects in atrial fibrillation in the heart, but very little is known about its expression in the human eye. This project hypothesizes that the dysregulation of PANCR, which causes mutations in the PITX2 gene, will cause deformities to the human eye, similar to those of Axenfeld-Rieger Syndrome, a disease effecting the development of the eye by mutations of the PITX2 gene.

Publication Date

2020

Department

Biology

Recommended Citation

Najjar, Mohamed, "Effects of the Dysregulation of PANCR Regarding the PITX2 Gene in the Eye" (2020). Undergraduate Research Posters 2020. 8.
https://engagedscholarship.csuohio.edu/u_poster_2020/8

Student Publication

This item is part of the McNair Scholars Program.